Synthesis and biological activity studies of furan derivatives

Abstract

The organic compounds, 4-Ethyl-2synthesized and purified through column chromatography and preparative TLC. All compounds were characterized by IR, 1 H, 13 C NMR, MS, and microanalysis. The in vitro antibacterial and antifungal activities of these compounds were investigated against some bacteria and fungi. The antibacterial and antifungal activities were measured by using the disc-diffusion method against gram-positive bacteria, i.e., Staphylococcus aureus ATCC 25923, Staphylococcus enteritidis ATCC1376, Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium gram-negative bacteria Escherichia coli ATCC 27853, Listeria monocytogenes ATCC 7644, and as fungus Micrococcus Luteus NRRLB was used. All compounds in this study showed activity against test bacteria. Their antibiogram tests showed better results than some known antibiotics.

Synthesis of furan substituted dihydrofuran compounds by radical cyclization reactions mediated by manganese(III) acetate

“…10,[20][21][22][23][24] Manganese(III) acetate dihydrate (98%) was prepared using an electrochemical method according to the literature. 25 All compounds were purified through column chromatography or preparative TLC and characterized by IR, 1 H-NMR, 13 C-NMR, 19 F-NMR, HMBC, NOSY, LC/MS, and microanalysis. Melting points were determined using a Gallenkamp capillary melting point apparatus.…”

“…IR spectra (KBr disc) were obtained with a Matson 1000 FTIR spectrometer in the 400-4000 cm -1 range with 4cm -1 resolution. 1 H-NMR, 13 C-NMR and 19 F-NMR spectra were recorded on a Bruker DPX-400 MHz High Performance Digital FT-NMR spectrometer. The mass spectra were measured on a Micromass UK Platform II spectrophotometer.…”

“…Also, 3-cyanodihydrofurans synthesized by our group has shown anti-bacterial and anti-fungal activities. 13 In this study, aiming the synthesis of the 2-furyl substituted dihydrofuran compounds (3a-e, 4a-d, 5a-d) was used as 1,1-and 1,2-disubstituted alkenes with 1,3-dicarbonyl compounds…”

Synthesis and antifungal activity of new dihydrofurocoumarins and dihydrofuroquinolines

“…We have also recently reported that some 3-cyano-4,5-dihydrofurans show antifungal and antibacterial activities. 21 Lunacrine, bucharaminol, acrophylline, dicramnine, isotaifine, araliopsine, almein, and oligophylidine are quinoline alkaloids commonly found in nature. It is reported that these compounds show antiparasitic, anthelmintic, cytotoxic, antiarrhythmic, spasmolytic, sedative, antitumor, and antimalarial activities.…”

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“…The synthesis of furan derivatives has engrossed substantial attention from organic and medicinal chemists for many years as they belong to a class of compounds with proven utility in medicinal chemistry 10 . Furan derivatives are known to be associated with multiple biological activities 11,12 . Therefore, both the pyrimidine and furan possess worthy and imperative bioactivities, which render them useful substances in drug research.…”