The in vitro antibacterial and antifungal activities of five different amino acid Schiff bases derived from the reaction of 2-hydroxy-1-naphthaldehyde with glycine, L-alanine L-phenylalanine, L-histidine, L-tryptophane and the manganese(III) complexes of these bases were investigated. Structures of the Schiff bases were proven by 1H-NMR. In vitro activities against some Gram-positive (Staphylococcus aureus and Bacillus polymyxa) and Gram-negative (Escherichia coli) bacteria and the fungus Candida albicans were determined. The antimicrobial activities tended to decrease with the increasing size of the amino acid residues.
The organic compounds, 4-Ethyl-2synthesized and purified through column chromatography and preparative TLC. All compounds were characterized by IR, 1 H, 13 C NMR, MS, and microanalysis. The in vitro antibacterial and antifungal activities of these compounds were investigated against some bacteria and fungi. The antibacterial and antifungal activities were measured by using the disc-diffusion method against gram-positive bacteria, i.e., Staphylococcus aureus ATCC 25923, Staphylococcus enteritidis ATCC1376, Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium gram-negative bacteria Escherichia coli ATCC 27853, Listeria monocytogenes ATCC 7644, and as fungus Micrococcus Luteus NRRLB was used. All compounds in this study showed activity against test bacteria. Their antibiogram tests showed better results than some known antibiotics.
With the aim of developing potential antimicrobials, a series of 2-amino-3-cyanopyridines incorporating both sulfur and oxygen as part of the heteroaromatic ring (methyl thiophene, methyl furan) and fused cycloalkane groups were synthesized and characterized by FTIR, 1 H-NMR, 13 C-NMR, and bases of elemental analysis. All synthesized compounds were evaluated for their in vitro antibacterial and antifungal activity. Antibacterial and antifungal activities of aminocyanopyridines against Pseudomonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium (clinical isolate), the gram-positive bacterium Micrococcus luteus NRRLB 4375, and the fungus Candida albicans ATCC 90028 were studied. The relationship between the functional-group variation and the biological activity of the evaluated compounds is discussed.
In this work, several diterpenes including siderol, linearol and epicandicandiol were isolated from Sideritis sipylea Boiss collected from Izmir-Karaburun-Akdag, Turkey. In addition, diacetate derivatives of linearol and epicandicandiol were obtained. The antimicrobial activites of all these compounds against the bacteria Staphylococcus aureus (ATTC 25923), Bacillus subtilis (ATCC 6633), Escherichia coli (ATCC 11230), Pseudomonas aeruginosa (ATCC 27853) and the fungus Candida albicans (ATCC 90028) were studied. Antimicrobal activity was measured by the well-diffusion method. Except for C. albicans all microorganisms were tested against antibiotic discs in comparison with the studied compounds.
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