Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents

Comprehensive Review in Current Developments of Benzimidazole‐Based Medicinal Chemistry

“…5,6‐Dichloro‐1‐cyclopentyl‐1H‐benzo [d] imidazoles 134 ( a – c ) showed potent antiproliferative activity in cancer cell lines. Compound ( 134a ) inhibited cellular CDK9 activity and was capable of inducing apoptosis via downregulation of antiapoptotic proteins Mcl‐1 at the concentration used to elicit its cytotoxic GI 50 response . Benzimidazole–pyrimidine analogues were synthesized and screened for inhibiting at least four cancer‐related protein kinases, namely Aurora B, PLK1, FAK, and VEGFR2.…”

“…Coumarin-benzimidazole hybrids and benzimidazole-chromene derivatives were synthesized and evaluated their anticancer activity against tumor cells in a full panel of 60 cell lines. Compound (140) shows higher selectivity against leukemia cancer cells (CCRF-CEM, HL-60(TB), K-562, RPMI-8226), colon cancer cells (HCT-116, HCT-15), melanoma cancer cells (LOX IMVI, UACC-257), and breast cancer cells (MCF7, T-47D) (146). Benzimidazole clubbed with triazolo-thiadiazoles and triazolothiadiazines derivatives reported as anticancer agents.…”

Novel Synthesis of Imidazo‐based and Benzimidazo‐based privileged Templates on s‐Triazine Nucleus through a Phenoxyl Spacer

“…Considering the immensely rich diverse biological properties of s ‐triazine , imidazoles , and benzimidazoles , it was found of paramount interest to incorporate all these biologically active privileged pharmacophores into a single molecular framework by utilizing the reactivity of an active synthon imidate ester (Fig. ).…”

Efficient Microwave-Assisted Synthesis of N-(2-Alkyl/aryl-4-phenyl-1H-imidazol-1-yl)-2-phenylacetamides

“…[1][2][3][4] The imidazole derivatives with different biological activities, including antimicrobial, [5] anticonvulsant, [6] anticancer, [7,8] and antiviral, [9] are present in the literature. Also, many of today's drugs include imidazole skeleton in their structure such as Clonidine (a 2 adrenergicagonist), Idazoxan, and Napamazole (antidepressant) [3,10,11] (Fig.…”