Synthesis and biological evaluation of lipid-like 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole derivatives as potential anticancer and antimicrobial agents

Abstract

The observed coupling of high anticancer and antimicrobial activity for novel lipid-like compounds9,10and13based on the 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole scaffold can be important as a basis for further drug development.

Synthesis of silver nanoparticle-loaded sulfadiazine/polyvinyl alcohol nanorods and their antibacterial activities

“…The final agar plates with bacterial suspensions were incubated at 37 °C for 24 h. The number of surviving colonies was counted to get the MBC values of the samples. 2 The antibacterial activity of the Ag-SD/PVA NRs against the tested strains was also measured by the cup diffusion method. 18 Nutrient agar was first spread onto a Petri plate, and then 100 μL of a bacterial suspension was coated on the agar plate.…”

“…Since increasing microbial infection events occur, there has been growing interest in the development of new and effective antibacterial agents. [1][2][3][4] It is well known that silver-based compounds are widely used in antibacterial materials because of their high antibacterial activity and broad antibacterial spectrum. 5,6 For example, silver sulfadiazine (SSD) is used in burn therapy.…”

Synthesis and Antibacterial Evaluation of Bis‐thiazolium, Bis‐imidazolium, and Bis‐triazolium Derivatives

“…[4][5][6] In particular,p olycationicc ompounds are less prone to induceb acterial resistance than the classical monocationic compounds, which are still in commercial use. [4,13] The latter compounds were found to be as potent as their classical ammonium counterparts, but were much less toxic on ar odentm odel.W ew ondered whether thesep ositivelyc hargedh eterocyclesc ould also exhibit attractive antibacterial activity.H owever,s ome mono-thiazolium compounds showed low potency on reference bacterial strains, [14] but we envisioned that dimeric analoguesc ould be much more active. Thus, some efforts have been made to correlate the structural features of QACs and both their antibacterial activity and eukaryotic toxicity.…”

“…[12] Later, analogousc ompounds were prepared, in which the cationic charges were harbored by thiazolium moieties. [4,13] The latter compounds were found to be as potent as their classical ammonium counterparts, but were much less toxic on ar odentm odel.W ew ondered whether thesep ositivelyc hargedh eterocyclesc ould also exhibit attractive antibacterial activity.H owever,s ome mono-thiazolium compounds showed low potency on reference bacterial strains, [14] but we envisioned that dimeric analoguesc ould be much more active. Thus, we prepared numerous derivatives and tested them against reference bacterial strains.…”