Synthesis and biological evaluation of an epidermal growth factor receptor-targeted peptide-conjugated phthalocyanine-based photosensitiser

Xue, Evelyn Y.; Wong, Roy C. H.; Wong, Chi‐Ming; Fong, Wing‐Ping; Ng, Dennis K. P.

doi:10.1039/c9ra03911b

Cited by 20 publications

(33 citation statements)

References 46 publications

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“…Various peptides that selectively target EGFR have been isolated and successfully implemented in PDT (Table 3). HT29 cells in female Balb/c nude mice [110] Cyclic CMYIEALDKYAC Zinc phthalocyanine (ZnPc) HT29, HCT116, HeLa, HEK293…”

Section: Egfr-targeting Peptidesmentioning

confidence: 99%

“…HT29 cells in female Balb/c nude mice [111] Using solid-phase synthesis, Ng et al, synthesized different bioconjugates by coupling Zn-phthalocyanine(ZnPc)-based photosensitizers with EGFR-targeting peptides, such as LARLLT (D4) [105,108], QRH* [110], and YHWYGYTPQNVI (GE11) [109]. The photophysical properties, cellular uptake, in vitro cytotoxicity, and in vivo biodistribution of the bioconjugates were examined.…”

Section: Egfr-targeting Peptidesmentioning

confidence: 99%

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EGFR-Targeted Photodynamic Therapy

et al. 2022

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The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are hallmarks of many human malignancies. As such, EGFR-targeted therapies hold significant potential for the cure of cancers. In recent years, photodynamic therapy (PDT) has gained increased interest as a non-invasive cancer treatment. In PDT, a photosensitizer is excited by light to produce reactive oxygen species, resulting in local cytotoxicity. One of the critical aspects of PDT is to selectively transport enough photosensitizers to the tumors environment. Accordingly, an increasing number of strategies have been devised to foster EGFR-targeted PDT. Herein, we review the recent nanobiotechnological advancements that combine the promise of PDT with EGFR-targeted molecular cancer therapy. We recapitulate the chemistry of the sensitizers and their modes of action in PDT, and summarize the advantages and pitfalls of different targeting moieties, highlighting future perspectives for EGFR-targeted photodynamic treatment of cancer.

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Section: Egfr-targeting Peptidesmentioning

confidence: 99%

Section: Egfr-targeting Peptidesmentioning

confidence: 99%

EGFR-Targeted Photodynamic Therapy

et al. 2022

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“…For colorectal cancer treatment in the pre-, early-, and late-tumor phase, 17 EGFR-specific peptides were selected by phage display: QRHKPRE, HAHRSWS, YLTMPTP, TYPISFM, KLPGWSG, IQSPHFF, YSIPKSS, SHRNRPRNTQPS, NRHKPREKTFTD, TAVPLKRSSVTI, GHTANRQPWPND, LSLTRTRHRNTR, RHRDTQNHRPTN, ARHRPKLPYTHT, KRPRTRNKDERR, SPMPQLSTLLTR, and NHVHRMH (Patent WO 2016/029125 A1—Peptide reagents and methods for detection and targeting of dysplasia, early cancer, and cancer). In the photodynamic therapy of colorectal adenocarcinoma, the peptide QRHKPRE was conjugated with zinc phthalocyanine to be used for photodynamic therapy of colorectal adenocarcinoma [ 105 ]. The KLPGWSG peptide was used to target murine neural stem cells for nerve regeneration, as it stimulated cell differentiation toward the neuronal phenotype [ 106 ].…”

Section: The Epidermal Growth Factor Receptor Familymentioning

confidence: 99%

Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy

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Mimmi

et al. 2021

Viruses

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Receptor tyrosine kinases (RTKs) regulate critical physiological processes, such as cell growth, survival, motility, and metabolism. Abnormal activation of RTKs and relative downstream signaling is implicated in cancer pathogenesis. Phage display allows the rapid selection of peptide ligands of membrane receptors. These peptides can target in vitro and in vivo tumor cells and represent a novel therapeutic approach for cancer therapy. Further, they are more convenient compared to antibodies, being less expensive and non-immunogenic. In this review, we describe the state-of-the-art of phage display for development of peptide ligands of tyrosine kinase membrane receptors and discuss their potential applications for tumor-targeted therapy.

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“…Alongside high production costs, heterogeneity of samples can result in poor reproducibility. Recently, the targeting ability of peptides has increased in popularity [10][11][12][13][14][15] as these chemically synthesised molecules can overcome many of the disadvantages that proteins present, while still maintaining selectivity towards the desired target.…”

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confidence: 99%

Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

et al. 2021

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Synthesis and biological evaluation of an epidermal growth factor receptor-targeted peptide-conjugated phthalocyanine-based photosensitiser

Abstract: A peptide-conjugated zinc(ii) phthalocyanine has been prepared which can selectively bind to the epidermal growth factor receptor of cancer cells and induce high cytotoxicity upon illumination.

Cited by 20 publications

References 46 publications

EGFR-Targeted Photodynamic Therapy

EGFR-Targeted Photodynamic Therapy

Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy

Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

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