Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives

Manjunatha, K.; Poojary, Boja; Lobo, Prajwal L.; Fernandes, J.; Kumari, N. Suchetha

doi:10.1016/j.ejmech.2010.08.039

Cited by 133 publications

(72 citation statements)

References 23 publications

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“…Carbon, nitrogen, hydrogen contents were analyzed using LECO 9320 analyzer. Aroylhydrazines 1 [34], 4-formylpyrazoles 2 [35] utilized in present investigation were synthesized according to the literature methods.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Some Aroylhydrazones and 2,5-Disubstituted-1,3,4- Oxadiazoles as DNA Photocleaving Agents

Kumar¹,

Kumar²,

Beniwal³

et al. 2016

Med chem (Los Angeles)

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Some 2,5-disubstituted-1,3,4-oxadiazole derivatives have been synthesized conveniently via oxidative cyclization of various synthesized aroylhydrazones by (diacetoxyiodo)benzene in dichloromethane under mild reaction conditions. In addition, the effect of electron-withdrawing/releasing groups on the formation of oxadiazole nucleus has also been studied. Compounds were obtained in good yields and their structures have been established on the basis of their FT-IR, 1 H, 13 C NMR and mass spectral data. Herein, a total of 42 compounds (hydrazones as well as oxadiazoles) were synthesized and investigated for their DNA photocleavage potential using plasmid DNA. It has been observed that aroylhydrazones showed good DNA photocleavage activity in comparison to their corresponding oxadiazoles.

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Section: Methodsmentioning

confidence: 99%

Synthesis of Some Aroylhydrazones and 2,5-Disubstituted-1,3,4- Oxadiazoles as DNA Photocleaving Agents

Kumar¹,

Kumar²,

Beniwal³

et al. 2016

Med chem (Los Angeles)

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“…For the treatment of microbial infections, the synthesis of new class of antimicrobial compounds effective against pathogenic microorganisms has become an urgent need. For this purpose, several compounds that contain a 1,2,4-triazole possessing antimicrobial activity have been synthesized; [1][2][3][4][5] some of which contains a Schiff base structure, [6][7][8][9] piperazine or morpholine moiety as well. 10,11 Also, the thione substituted 1,2,4-triazole ring systems have been synthesized and so far a variety of biological activities have been reported for a large number of their derivatives.…”

Section: Introductionmentioning

confidence: 99%

Convenient One Pot Synthesis and Antibacterial Evaluation of Some New Mannich Bases Carrying 1,2,4‐Triazolyl Moiety

Arafa

Mohamed

2011

Chin. J. Chem.

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A series of Mannich bases were synthesized by a three-component Mannich reaction. The newly synthesized compounds were well characterized by elemental analyses, IR, NMR and mass spectroscopic studies. The potential antibacterial effects of the synthesized compounds were investigated using standard bacterial strains: Gram-positive and Gram-negative bacteria. Interestingly, all the synthesized compounds were observed to be promising leads, possessing moderate to significant inhibitory activity as compared to standard.

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“…Ibuprofen, chemically called 2-(4-isobutyl phenyl) propionic acid, is a well known analgesic which possess potent pain relieving, anti pyretic and anti-inflammatory properties 14,15 . It is particularly known for its use in pain relief from arthritis 16 .…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements and Biological Activities of Aryl Propionic Acid Derivatives: A Review

Dhall¹,

Sikka²,

Kumar³

et al. 2016

Orient. J. Chem

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The aryl propionic acid derivatives belong to an important class of NSAIDs (Non Steroidal Anti-inflammatory Drugs). Ibuprofen, chemically called 2-(4-isobutyl phenyl) propionic acid, is a well known NSAID. Aryl propionic acid derivatives possesses a wide range of biological activities including anti-bacterial, anti-convulsant, anti-cancer, analgesic and anti-inflammatory activities. Apart from very potent compounds in the field of analgesics and antipyrectics as Ibuprofen, Oxaprozin, Ketoprofen, Fenoprofen; aryl propionic acid derivatives plays important role to treat other ailments also. Through this review, an attempt has been made to emphasize on recent work done and recent advancements in arena of aryl propionic acid derivatives in view of medicinal chemistry.

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Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives

Cited by 133 publications

References 23 publications

Synthesis of Some Aroylhydrazones and 2,5-Disubstituted-1,3,4- Oxadiazoles as DNA Photocleaving Agents

Synthesis of Some Aroylhydrazones and 2,5-Disubstituted-1,3,4- Oxadiazoles as DNA Photocleaving Agents

Convenient One Pot Synthesis and Antibacterial Evaluation of Some New Mannich Bases Carrying 1,2,4‐Triazolyl Moiety

Recent Advancements and Biological Activities of Aryl Propionic Acid Derivatives: A Review

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