Synthesis and Biological Evaluation of Novel 6-(3-(4,5-Dihydro-1,5-diphenyl-1<i>H</i>-pyrazol-3-yl)phenylamino) Pyridazin-3(2H)-one Derivatives

Abstract

Pyrazoles are important nitrogen containing 5-membered heterocyclic compounds. Numerous pyrazoline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. Several 1,3,5-Triphenyl-1H-pyrazole containing 6-aminopyridazin-3(2H)-one derivatives has been synthesized. These new compounds were characterized using IR, 1 H-NMR and Mass spectra and Elemental analysis. They possess some potent biological activities. Therefore biological screening of novel compounds has been also done.

Synthesis and Characterization of 2-Phenylpyrazoline Derivatives and Evaluation of their Activities against Antimicrobial and Breast Cancer Cell Line in vitro and in silico Studies

“…Among various pyrazoline derivatives, 2-pyrazolines derivative of compounds is mostly studied [7]. Pyrazoline compounds have adjacent two nitrogen atom occur from saturated and partially saturated pyrazoles in biologically active compounds and natural products [8]. Pharmacologically interesting heterocyclic systems like pyrazoline derivatives have been widely studied to their pharmacological activities such as antitumor, anti-inflammatory, antiparasitary, anticonvulsant, antimicrobial, antinociceptives, antimalarial, Alzheimer, Huntington and inflammatory arthritis, anticancer, antiviral, antioxidant, antiamoebic, antifungal, antidiabetic, cytotoxic and pesticidal properties [9].…”