Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers

A fluorescent probe for the dual detection of mercury ions and thiols based on a simple coumarin derivative

“…The resulting white solid was filtered and purified by column chromatography on silica gel with petroleum ether/ethyl acetate (8:1, v/v) as eluent to afford 2 (1.85 g, 86%). Mp: 100‐101°C (literature value: 103‐104°C) . IR (KBr pellet) ν = 3464, 1726, 1624, 1560, 1397, 1274, 1145, 1066, 935, 843 cm –1 .…”

Synthesis Through Three‐Component Reactions Catalyzed by FeCl3 of Fused Pyridocoumarins as Inhibitors of Lipid Peroxidation

“… In the course of our interest on the synthesis of fused pyridocoumarin derivatives, we wish to report here the application of FeCl 3 catalysis in the synthesis of the title compounds by using the three‐component domino reactions with aminocoumarins, benzaldehyde, and phenylacetylene. On the basis of our previous experience on the antioxidant and antilipid peroxidation properties of coumarin derivatives, we screened the synthesized compounds in vitro for their antioxidant profile. The reactions studied and the products obtained are depicted in Schemes and .…”

Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties

“…The reactions studied and the title new compounds received are depicted in Schemes ( 1 - 5 ). The nitrile oxide, generated from the oxime 2a [ 18 ] by chlorination with NCS in DMF solution followed by addition of Et 3 N in an one-pot procedure, was treated with the allyloxycoumarin 3a [ 19 ] under stirring for 24 h and Ar atmosphere (Scheme 1 ) to give the isoxazoline 4a in 68% yield (Table 1 , entry 1). The isoxazoline 4a has the expected regiochemistry [ 18 ] as indicated by HMBC experiments.…”