Synthesis and biological evaluation of formazan derivatives

Abstract

The formazan derivatives (FM1–FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, 1H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. All the compounds showed remarkable antibacterial activity at 250 μg/ml, but FM4 and FM3 did not show any inhibition on Staphylococcus aureus and Vibriocholera, respectively. All the compounds showed significant anticonvulsant effect at 100 mg/kg p.o. and the experimental data were statistically significant at P<0.001 level. But none of the compounds was effective against Japanese encephalitis virus.

Synthesis, crystal structure, optical and electrochemical properties of novel diphenylether-based formazan derivatives

“…35,36 The observation of weak bands in the range of 3055-3093 cm À1 for all compounds indicated the existing of intramolecular hydrogen bond in formazans. 13,17,40 The observation of these values confirm the presence of pseudo aromatic -NH-N molecular hydrogen bond in a formazan skeleton (-NH-NQC-NQN-) (Scheme 2). 37,38 The observation of intense bands between 1461-1496 cm À1 indicated the -NQN-group, which was in good agreement with the reported FTIR values.…”

Synthesis of Metal Complexes of Some Formazans Obtaining From Cinnamaldehyde and Investigation of Their Dyeing Properties Using Different Methods

“…The 13 C-NMR spectra data of formazans and metal complexes were listed in Table 4. Therefore, we draw conclusions from Table 4 that the C=N peaks observed at 144.03 and 151.17 ppm in formazans (1 and 2) [4,30] and shifted towards high fields in the M(II) complexes. This result confirms the structure given in Scheme 1.…”

Frontiers of Formazans Chemistry: A Review

“…Marriappan et al [30] synthesized the hetarylformazan derivatives (XIV) by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and heteroaromatic amines (1-…”

“…antifertility activity, [180] antiinflammatory active, [181][182][183][184][185][186][187][188] antiviral activity, [189][190][191][192][193][194] anti-tubercular activity, [195][196][197] anticancer and anti HIV activities, [198][199][200][201][202] anticonvulsant activity, [203][204][205] anthelmintic activity, [206][207] antiparkinsonian activity, [208][209] cardiovascular activity, [210] antiproliferative activity, [211] analgesic activity [212] as markers of cell vitality and antioxidant activity [212][213][214][215][216][217][218][219][220][221][222][223][224][225]…”