Synthesis and biological evaluation of 3,5-substituted pyrazoles as possible antibacterial agents

Available synthetic protocols for 3,5‐diaryl‐1H‐pyrazoles generally demand long reaction time. Herein, we are reporting a CuFe2O4 catalyzed synthetic procedure for the same that delivers products in significantly reduced time starting from tosylhydrazones of aromatic aldehydes and terminal alkynes. Under the reaction condition, tosylhydrazone generates diazo compound in situ, which then undergoes [3 + 2] cycloaddition reaction with the terminal alkyne followed by [1,3]‐H shift to deliver the final products in 72%–85% isolated yield. Magnetically active CuFe2O4 nanoparticles can be recovered very easily after the completion of the reaction and can be reused up to fifth cycle without significant loss in its catalytic activity. Operational simplicity of the methodology along with tolerability of various functional groups as well as easy recovery and high reusability of CuFe2O4 nanoparticles make the procedure a practical and handy one for the synthesis of 3,5‐diaryl‐1H‐pyrazoles.

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Base promoted CuFe₂O₄ catalyzed one‐pot synthesis of 3,5‐diaryl‐1H‐pyrazoles

Bhuyan

Saikia

2021

Journal of Heterocyclic Chem

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Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Kapri,

Gupta,

Nain

2024

Pharm Chem J

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Antibacterial and antifungal pyrazoles based on different construction strategies

Rehman,

He,

Shu

et al. 2025

European Journal of Medicinal Chemistry

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Synthesis and biological evaluation of 3,5-substituted pyrazoles as possible antibacterial agents

Cited by 9 publications

References 28 publications

Base promoted CuFe₂O₄ catalyzed one‐pot synthesis of 3,5‐diaryl‐1H‐pyrazoles

Base promoted CuFe₂O₄ catalyzed one‐pot synthesis of 3,5‐diaryl‐1H‐pyrazoles

Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Antibacterial and antifungal pyrazoles based on different construction strategies

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Product

Resources

About

Synthesis and biological evaluation of 3,5-substituted pyrazoles as possible antibacterial agents

Cited by 9 publications

References 28 publications

Base promoted CuFe2O4 catalyzed one‐pot synthesis of 3,5‐diaryl‐1H‐pyrazoles

Base promoted CuFe2O4 catalyzed one‐pot synthesis of 3,5‐diaryl‐1H‐pyrazoles

Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Antibacterial and antifungal pyrazoles based on different construction strategies

Contact Info

Product

Resources

About

Base promoted CuFe₂O₄ catalyzed one‐pot synthesis of 3,5‐diaryl‐1H‐pyrazoles

Base promoted CuFe₂O₄ catalyzed one‐pot synthesis of 3,5‐diaryl‐1H‐pyrazoles