Synthesis and biological studies of Co(II) and Cd(II) 5-(3,4,5- trimethoxybenzyl) pyrimidine-2,4-diamine (Trimethoprim) complexes

Abstract

Two metal complexes of Co(II) and Cd(II) 5-(3,4,5-trimethoxybenzyl) pyrimidine-2,4-diamine (Trimethoprim) were synthesized and characterized by both analytical and spectroscopic methods. They are 4-coordinate complex containing two molecules of 5-(3,4,5-trimethoxybenzyl) pyrimidine-2,4-diamine (TMP) and two chloride ions. A distorted tetrahedral geometry is suggested for their structure, where TMP behaves as a monodentate ligand. The metal binds through the pyrimidine N(1) of the ligand. The complexes have been screened for antiplasmodial activity against Plasmodium berghei and the results show that they are less active than the parent ligand. Toxicological study was carried out by investigating the effect of administration of the complexes on alkaline phosphatase activity of kidney, liver and serum of albino rats and they are found to be nontoxic.

Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

“…. Following the results obtained in this studies, percentage (%) reduction in parasitemia for the synthesized compounds were more potent or active as compared to similar complexes reported by Tella and Obaleye (2010) with activities less than 70% as obtained in this study.…”

“…It could be a result of the coordination of the ligands to the metal ions which improve the effectiveness of the drug. It could also be observed that Co(II) and Zn(II) complexes exhibited the same antimalaria activity at 70 percent (Tella and Obaleye, 2010). The parasitemia level was determined by the number of erythrocytes that are being infected with the organisms: Plasmodium berghei.…”

“…The antimalarial study was investigated following the procedure. (Tella and Obaleye, 2010). Plasmodium berghei (NK 65 strain) was collected from Nigeria Institute of Medical Research and the parasites were maintained weekly by blood passage in mice.…”

Toxicological and Antibacterial Studies of Mixed Amodiaquine-Anthranilic Acid Metal-Drug Complexes: Synthesis and Characterization

“…Based on the research work of Tella et al 12 , coordination complexes can be used as chemotherapy for the treatment of metal intoxication. Bamigboye and Ejidike 13 reported the characterization, antimalarial and antimicrobial activities of mixed ibuprofenpyrimethamine metal complexes.…”

“…Drugs combination improves the effectiveness of chemotherapeutic agents towards bacteria and parasite cell inhibitions 17 . It has also been sustained that combination therapy gives an effective action in bacteria resistant situation owing to previous research [10][11][12][13][14] would have an improved therapeutic action such as antibacterial and toxicological activities. The administration of the metal-drug samples to experimental animals (albino rats) was carried out in order to determine medical effect of the graded doses of the samples using biochemical parameters of the blood samples and essential organ like liver of these experimental animals.…”