“…Heterocycles, especially nitrogen-containing compounds, have attracted considerable attention due to their wide spectrum and important biological uses in the fields of medicines, pharmacology, pharmaceutics, and pharmaceuticals. Heterocycles furans and benzofuran [16], pyrazoles [17], thiophenes [18], oxadiazoles [19], 1,2,4-Amino-triazines [20], thiadiazoles [21], imidazoles benzimidazoles, triazoles, pyridines, pyrimidines, benzoxazoles, benzothiazoles [22,23], etc., constitute the integral part of most of the clinical drugs and ther-apeutics to treat various diseases such as antiviral, anti-cancer, anti-bacterial, anti-allergic, anti-diabetic, analgesic, anti-histamine, anti-inflammatory, anti-tuberculosis, hemolytic, anti-convulsant, thrombolytic, anti-neurodegenerative, anti-leprosy, anti-tumor, antifungal, antipyretics, antihypertensive, dehydrogenase kinase inhibitor, herbicidal, etc. [16][17][18][19][20][21][22][23].…”