Synthesis and characterisation of biologically compatible TiO2 nanoparticles

Cheyne, Richard W.; Smith, T.; Trembleau, Laurent; Mclaughlin, Abbie C.

doi:10.1186/1556-276x-6-423

Cited by 41 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carboxylate binding site can be identified at ∼ 1620 cm −1 , and ∼ 1521 cm −1 , carboxylate peaks are detected at 1630 and 1513, while C C aromatic stretch is detected at 1599 cm −1 . 35 Hence, the chemisorption of fumaric acid on TiO 2 occurs most probably through the two trans-carboxylic acid groups due to the strong affinity of TiO 2 towards COO − groups. 16 35 The EDAX analysis was carried out to determine the elemental composition of the nanocomposite samples.…”

Section: Synthesis Of Fumaric Acidmentioning

confidence: 99%

Synthesis and Characterization of Fumaric Acid Functionalized AgCl/Titania Nanocomposite with Enhanced Antibacterial Activity

Desai¹,

Kowshik²

2013

j. nanosci. nanotech.

View full text Add to dashboard Cite

Silver based antimicrobial agents with TiO2 as a host support (AgCl/TiO2) are increasingly being evaluated for disinfection and therapeutic applications. In this work TiO2 supported silver chloride nanocomposites were synthesized and functionalized with fumaric acid. X-ray diffraction results showed that the TiO2 was in anatase phase and AgCI was in the cubic chalcoargyrite phase. The functionalization was confirmed by FTIR analysis. The fumaric acid functionalized AgCl/TiO2 (Fu-AgCl/TiO2) showed uniform particle size distribution in the range of 4-5 nm. The intensity size distribution of Fu-AgCl/TiO2 nanocomposite by DLS showed an average particle diameter of -290 nm with a polydispersity index (P. I.) of 0.47. Further, a high BET surface area of -320.7 m2/g was observed for Fu-AgCl/TiO2 with an average pore size distribution of 3.8 nm. The antimicrobial activity of Fu-AgCl/TiO2 and AgCl/TiO2 was evaluated by determining the MIC and MBC values, and it was observed that Fu-AgCl/TiO2 exhibited better antimicrobial activity as compared to the unfunctionalized nanocomposite. The antimicrobial activity of Fu-AgCl/TiO2 is mainly attributed to its superior physicochemical properties coupled with the synergistic action of both fumaric acid and silver ions. The changes in the cytoplasmic membrane of the cells due to the formation of intracellular ROS were observed by SEM imaging.

show abstract

Section: Synthesis Of Fumaric Acidmentioning

confidence: 99%

Synthesis and Characterization of Fumaric Acid Functionalized AgCl/Titania Nanocomposite with Enhanced Antibacterial Activity

Desai¹,

Kowshik²

2013

j. nanosci. nanotech.

View full text Add to dashboard Cite

show abstract

“…MSA is a short chain carboxylic acid, and is known as a surface modifier that makes various particles highly dispersible in water. The reported MSA-modified particles include metal particles (e.g., Au [19], Ag [20], Pt [21]), semiconductor particles (e.g., CdS [22], CdSe [23], CdTe [24], TiO 2 [25]) and magnetic particles (e.g., Fe 3 O 4 [26]). Here, for the first time, we produce MSA-modified Si particles to be used as ink particles, and evaluate their structural and electrical properties.…”

Section: Introductionmentioning

confidence: 99%

Mercaptosuccinic acid modified silicon particle inks: Production, structural, and electrical characterizations

Sato

Dobashi

Matsuda

2015

Chemical Engineering Journal

View full text Add to dashboard Cite

“…Titanium oxide (TiO 2 ) nanoparticles have attracted major attention in the biomedical field owing to very good cell and biocompatibility, chemical inertness and stability under physiological conditions, and a plethora of biological features . Nano‐TiO 2 has also been proposed in drug delivery .…”

Section: Introductionmentioning

confidence: 99%

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Melnitzer

Sosnik

2018

Adv Funct Materials

View full text Add to dashboard Cite

This work describes for the first time the synthesis of hybrid drug-loaded TiO 2 /polymer amphiphilic nanoparticles of finely controlled size utilizing a simple and reproducible sol-gel process that comprises the formation of a titanium(IV)/acetone oxo-organo complex followed by its blending with an amphiphilic poly(ethylene oxide)-b-poly(propylene oxide) block copolymer in acetone and its aqueous-phase nanoprecipitation. The size of the hybrid nanoparticles is governed by the complex aging, e.g., hybrid nanoparticles display diameter between 228 and 53 nm for aging of 1 and 36 days, respectively (dynamic light scattering). In addition, they show excellent physical stability in water owing to the coating of the surface with poly(ethylene oxide) blocks of the copolymer. Conversely, polymer-free TiO 2 particles are large and precipitate fast. Incorporation of a model hydrophobic drug, nitazoxanide, to the precursor solution results in hybrid nanoparticles containing 12.9% w/w cargo that is released following a bimodal profile. High-resolution transmission electron microscopy (Titan Cubed Themis G2 300) analysis reveals the porous amorphous nanostructure of these novel hybrids and colocalization of drug and copolymer in the nanoparticle bulk. Finally, upon ultrasonication, our hybrid nanoparticles produce reactive oxygen species in vitro which paves the way for their use in sonodynamic and drug release therapies.

show abstract

Synthesis and characterisation of biologically compatible TiO2 nanoparticles

Cited by 41 publications

References 20 publications

Synthesis and Characterization of Fumaric Acid Functionalized AgCl/Titania Nanocomposite with Enhanced Antibacterial Activity

Synthesis and Characterization of Fumaric Acid Functionalized AgCl/Titania Nanocomposite with Enhanced Antibacterial Activity

Mercaptosuccinic acid modified silicon particle inks: Production, structural, and electrical characterizations

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Contact Info

Product

Resources

About