Synthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)

Abstract

New derivatives of 1,3,4-oxadiazole, synthesized by the condensation of different substituted benzoic acids with 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl) acetohydrazide using SOCl 2 as well as POCl 3 as cyclization reagents. Ethyl-2-(1-phenyl-1,2,3,4-tetrahydroisoquinoline)-ethaonate was synthesized from 1,2,3,4-Tetrahydroisoquinoline and it was converted to the 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl)acetohydrazide. This compound is the key intermediate for the 1,3,4-oxadiazole compounds. All the synthesized molecules were characterized by advanced spectral data and also studied their biological activity.