Synthesis and Characterization of 2-Pyridinylmethylene-2-quinolyl Hydrazone Cobalt(III) Complexes. Reactivity Trends and Solvent Effect on the Initial and Transition States of Base Catalyzed Hydrolysis

To assess electronic absorption spectra, molecular docking, and antibacterial activity, 12 new hydrazone compounds that have different substituents and in different positions were synthesized and characterized. HOMO–LUMO energies and theoretical electronic spectra of synthesized compounds were computed via Gaussian 09 software. Global reactivity descriptors were computed from HOMO–LUMO energies. In addition, 1JXA protein was used for molecular docking studies structure. Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 (as negative bacteria), Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853 (as gram positive) was selected. Compound 3 was observed to be the most effective against propagations of E. Coli. Similarly, compounds 7 and 9 were found to be the most effective against the reproduction of P. aeroginosa. The most powerful compound against the growth of E. faecalis was ascertained to be compound 7.

show abstract

“…Action in solvent of a dissolved compound is due to solute-solvent interactions. There are lots of article regarding this issue [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, investigation of biological activity, docking studies, and spectroscopic properties of hydrazone compounds containing different substituents

Yilmaz

Çukurovalı

2019

Can. J. Phys.

View full text Add to dashboard Cite

show abstract

Antimicrobial and anticancer activities of cobalt (III)-hydrazone complexes: Solubilities and chemical potentials of transfer in different organic co-solvent-water mixtures

Mohamad

Abualreish

Abu‐Dief

2019

Journal of Molecular Liquids

View full text Add to dashboard Cite

Synthesis and Characterization of 2-Pyridinylmethylene-2-quinolyl Hydrazone Cobalt(III) Complexes. Reactivity Trends and Solvent Effect on the Initial and Transition States of Base Catalyzed Hydrolysis

Cited by 2 publications

References 27 publications

Synthesis, characterization, investigation of biological activity, docking studies, and spectroscopic properties of hydrazone compounds containing different substituents

Synthesis, characterization, investigation of biological activity, docking studies, and spectroscopic properties of hydrazone compounds containing different substituents

Antimicrobial and anticancer activities of cobalt (III)-hydrazone complexes: Solubilities and chemical potentials of transfer in different organic co-solvent-water mixtures

Contact Info

Product

Resources

About