Synthesis and characterization of a novel controlled release zinc oxide/gentamicin–chitosan composite with potential applications in wounds care

Vasile, Bogdan Ștefan; Oprea, Ovidiu; Voicu, Georgeta; Ficai, Anton; Andronescu, Ecaterina; Teodorescu, Andrei George; Holban, Alina Maria

doi:10.1016/j.ijpharm.2013.11.035

Cited by 123 publications

(63 citation statements)

References 28 publications

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“…The composite gel of ZnO, GEN, and CS significantly improved the minimum inhibitory concentrations (MICs) against G+ and G− bacteria compared with the GEN control group ( Figure 10 ). 168 Bacterial CEL polymers grafted by RGDC (R: arginine; G: glycine; D: aspartic acid; C: cysteine) and GEN offered an inspiring and effective antibacterial composite 169. CIP was combined with different materials, from metal nanoparticles to amphiphiles, to develop synergetic effective antibacterial hydrogels.…”

Section: Hydrogels With Synergetic Effectsmentioning

confidence: 99%

Antibacterial Hydrogels

et al. 2018

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Antibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical research. Many advanced antibacterial hydrogels are developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs, and structural diversity. Here, an overview of the structures, performances, mechanisms of action, loading and release behaviors, and applications of various antibacterial hydrogel formulations is provided. Furthermore, the prospects in biomedical research and clinical applications are predicted.

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Section: Hydrogels With Synergetic Effectsmentioning

confidence: 99%

Antibacterial Hydrogels

et al. 2018

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“…10B. The figure consists of terpeniods and limonoids molecules that interact with divalent cations forming bridges between two hydroxyl / carbonyl groups from two different chains comes in close contact[51,52]. The divalent ions keep the molecules together and form superstructures along with supportive binding of two or more chains of terpeniods and limonoids.…”

mentioning

confidence: 99%

Facile green fabrication of nanostructure ZnO plates, bullets, flower, prismatic tip, closed pine cone: Their antibacterial, antioxidant, photoluminescent and photocatalytic properties

Madan

Sharma

Udayabhanu

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

218

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“…In one study [26], ZnO nanoparticles were coated with gentamicin and incorporated into the chitosan matrix to yield a ZnO/gentamicin-chitosan gel. This gel showed great antimicrobial properties, inhibiting S. aureus and P. aeruginosa growth in both planktonic and surface-attached conditions.…”

Section: Migratory Phasementioning

confidence: 99%

Recent developments in novel drug delivery systems for wound healing

Pachuau

2015

Expert Opinion on Drug Delivery

112

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Controlled and localized delivery of wound healing drugs to the wounds is more convenient than systemic administration as higher concentrations of the medication are delivered directly to the desired area in a sustained manner. They are also capable of providing optimum environmental conditions to facilitate wound healing while eliminating the need for frequent changes of dressings. As the number of people suffering from chronic wounds is increasing around the world, controlled delivery of wound healing agents have enormous potential for patient-friendly wound management.

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Synthesis and characterization of a novel controlled release zinc oxide/gentamicin–chitosan composite with potential applications in wounds care

Cited by 123 publications

References 28 publications

Antibacterial Hydrogels

Antibacterial Hydrogels

Facile green fabrication of nanostructure ZnO plates, bullets, flower, prismatic tip, closed pine cone: Their antibacterial, antioxidant, photoluminescent and photocatalytic properties

Recent developments in novel drug delivery systems for wound healing

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