Synthesis and Characterization of a New Nanocomposite Film Based on Polyvinyl Alcohol Polymer and Nitro Blue Tetrazolium Dye as a Low Radiation Dosimeter in Medical Diagnostics Application

Abstract

Dosimetry is a field of increasing importance in diagnostic radiology. There has been a realization among healthcare professionals that the dose of radiation received by patients via modern medical X-ray examinations could induce acute damage to the skin and eyes. The present study highlights the synthesis of polyvinyl alcohol/nitro blue tetrazolium nanocomposite films (PVA/NBT) for radiation detection depending on chromic, optical, chemical and morphologic changes. First, we synthesized the nanocomposite film-based PVA doped with NBT and the different parameters of the preparation procedure were optimized. Then The films were exposed to different low X-ray doses on the scale of mGy level (0, 2, 4, 10 and 20 mGy). The sensitivity and the performance of the made composite films were evaluated via different characterization methods. Indeed, the response curve based on UV-Vis absorptions revealed a linear increase in absorbance with increased radiation doses (R = 0.998). FTIR analysis showed a clear chemical modification in recorded spectra after irradiation. X-ray diffraction assessment revealed clear structural changes in crystallinity after ionization treatment. SEM analysis showed a clear morphological modification of PVA/NBT films after irradiation. In addition, the prepared PVA/NBT films exhibited excellent pre- and post-irradiation stability in dark and light. Finally, the quantitative colorimetry study confirmed the performance of the prepared films and the different colorimetric coordinates, the total color difference (∆E) and the color strength (K/S) showed a linear increase with increasing X-ray doses. The made nanocomposite PVA/NBT film might offer promising potential for an effective highly sensitive medical dosimeter applied for very low doses in X-ray diagnostic radiology.

Development, Characterization and Valuable Use of Novel Dosimeter Film Based on PVA Polymer Doped Nitro Blue Tetrazolium Dye and AgNO3 for the Accurate Detection of Low X-ray Doses

“…The films-based PVA polymers mixed with various amounts of NBT and silver nitrate fillers were developed following a previously reported casting method in our laboratory [ 45 ]. A 5% solution of PVA dissolved in distilled water was prepared.…”

“…The nitro tetrazolium blue dye is previously reported by our group as an efficient indicator of low radiation doses. Its compatibility with PVA polymer is conducive to the development of a practical and effective dosimeter [ 45 ]. The investigation of AgNO 3 with PVA thin film has demonstrated the easy formation of polymer metal chelate and the resulting film exhibited promising performance and sensitivity to low radiation doses [ 46 ].…”

Synthesis, Characterization, and Performance of Pyridomethene–BF2 Fluorescence Dye-Doped PVA Thin Film and PVP Nanofibers as Low γ-ray Dosimeters

“… 26 , 27 PVA has shown more opportunities due to its low cost, availability, nontoxicity, water solubility, and ability to incorporate a wide range of transition metal salts and dyes. 28 − 30 Currently, nanofibrous materials via different electrospinning technologies are widely reported and proven effective in various biomedical applications including tissue engineering, wound dressing, drug delivery, regenerative medicine, disease modeling, and detection/biodetection. 30 − 33 These sustainable electrospun composites were effective due to their ease of operation, nanoscale diameter, wide specific surface, high porosity, cost-effectiveness, and the considerable adaptability for engineering eco-friendly bioactive nanomaterials.…”

Dosimetric Performance of Poly(vinyl alcohol)/Silver Nanoparticles Hybrid Nanomaterials for Colorimetric Sensing of Gamma Radiation

“…Ag nanoparticles (AgNPs) have often been the material selected due to their biocompatibility [ 14 ] and unique physiochemical properties [ 15 ]. AgNPs are used in several diagnostic [ 16 ], therapeutic [ 17 ], and industrial applications [ 18 , 19 ].…”