Synthesis and Characterization of Acrylic Acid-g-(-Carrageenan) Copolymer and Study of Its Application

Srivastava, Arti; Kumar, Rajesh

doi:10.1155/2013/892615

Cited by 22 publications

(12 citation statements)

References 38 publications

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“…The grafting of arabinoxylan and AAc is confirmed by these vibration peaks. 32 , 33 The absorption peak at 2924 cm –1 is attributed to the stretching −CH group of the COOH groups and intramolecular bonding of O–H stretching of alcohols, respectively. 34 , 35 However, the absorption peaks at 2427 and 1728 cm –1 are attributed to the C=O stretching vibration.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Silver-Coated Polymeric Scaffolds for Bone Tissue Engineering: Antibacterial and In Vitro Evaluation of Cytotoxicity and Biocompatibility

et al. 2021

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In bone tissue engineering, multifunctional composite materials are very challenging. Bone tissue engineering is an innovative technique to develop biocompatible scaffolds with suitable orthopedic applications with enhanced antibacterial and mechanical properties. This research introduces a polymeric nanocomposite scaffold based on arabinoxylan- co -acrylic acid, nano-hydroxyapatite (nHAp), nano-aluminum oxide (nAl 2 O 3 ), and graphene oxide (GO) by free-radical polymerization for the development of porous scaffolds using the freeze-drying technique. These polymeric nanocomposite scaffolds were coated with silver (Ag) nanoparticles to improve antibacterial activities. Together, nHAp, nAl 2 O 3 , and GO enhance the multifunctional properties of materials, which regulate their physicochemical and biomechanical properties. Results revealed that the Ag-coated polymeric nanocomposite scaffolds had excellent antibacterial properties and better microstructural properties. Regulated morphological properties and maximal antibacterial inhibition zones were found in the porous scaffolds with the increasing amount of GO. Moreover, the nanosystem and the polymeric matrix have improved the compressive strength (18.89 MPa) and Young’s modulus (198.61 MPa) of scaffolds upon increasing the amount of GO. The biological activities of the scaffolds were investigated against the mouse preosteoblast cell lines (MC3T3-E1) and increasing the quantities of GO helps cell adherence and proliferation. Therefore, our findings showed that these silver-coated polymeric nanocomposite scaffolds have the potential for engineering bone tissue.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Silver-Coated Polymeric Scaffolds for Bone Tissue Engineering: Antibacterial and In Vitro Evaluation of Cytotoxicity and Biocompatibility

et al. 2021

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“…Consequently, the presence of all these peaks/bands and the demise of BG's O-H bending vibration is confirmation that AAc grafted the BG polysaccharide on the O-H site. These peaks/bands confirm the grafting of AAc on the backbone of the polysaccharide [43]. The adsorption peak at 947 cm −1 is due to C-O stretching [44].…”

Section: Resultsmentioning

confidence: 55%

Synthesis of Silver-Coated Bioactive Nanocomposite Scaffolds Based on Grafted Beta-Glucan/Hydroxyapatite via Freeze-Drying Method: Anti-Microbial and Biocompatibility Evaluation for Bone Tissue Engineering

et al. 2020

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Advancement and development in bone tissue engineering, particularly that of composite scaffolds, are of great importance for bone tissue engineering. We have synthesized polymeric matrix using biopolymer (β-glucan), acrylic acid, and nano-hydroxyapatite through free radical polymerization method. Bioactive nanocomposite scaffolds (BNSs) were fabricated using the freeze-drying method and Ag was coated by the dip-coating method. The scaffolds have been characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction analysis (XRD) to investigate their functional groups, surface morphology, and phase analysis, respectively. The pore size and porosity of all BNS samples were found to be dependent on silver concentration. Mechanical testing of all BNS samples have substantial compressive strength in dry form that is closer to cancellous bone. The samples of BNS showed substantial antibacterial effect against DH5 alpha E. coli. The biological studies conducted using the MC3T3-E1 cell line via neutral red dye assay on the scaffolds have found to be biocompatible and non-cytotoxic. These bioactive scaffolds can bring numerous applications for bone tissue repairs and regenerations.

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“…In the present study, the anti-inflammatory and analgesic effects of phonophoresis alone or in association with diclofenac diethylammonium was evaluated using an experimental model of carrageenan-induced paw edema in rats. Carrageenan is a sulfated polysaccharide extracted from seaweed that has been widely used in animal models of inflammation as a tool in the screening of novel anti-inflammatory drugs (17).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study

Cardoso

Pinto

Nobre

et al. 2019

Braz J Med Biol Res

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The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in two distinct models of acute inflammation. Edema was induced by an intraplantar injection of carrageenan and measured by plethysmography. The Hargreaves test was used to evaluate the antinociceptive activity and investigate the action of phonophoresis on tumor necrosis factor (TNF)-α production. A histological analysis with hematoxylin-eosin was used to evaluate tissue repair, and the expression of COX-2 was determined by immunohistochemical analysis. At the peak of inflammatory activity (3 h), treatment with US, US+DCF, and DCF significantly reduced edema formation compared to the control group. Treatment with US+DCF was more effective than treatment with US alone at both analyzed times. In the analysis of the antinociceptive activity, the treatments significantly increased the latency time in response to the thermal stimulus. Histopathological analysis revealed a reduction of the inflammatory infiltrates and immunohistochemistry demonstrated that the association was effective in reducing COX-2 expression compared to the control group. The association of DCF with US produced anti-inflammatory and antinociceptive effects in rat models of inflammation, which may be associated with inhibition of COX-2 and TNF-α production.

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Synthesis and Characterization of Acrylic Acid-g-(-Carrageenan) Copolymer and Study of Its Application

Cited by 22 publications

References 38 publications

Synthesis and Characterization of Silver-Coated Polymeric Scaffolds for Bone Tissue Engineering: Antibacterial and In Vitro Evaluation of Cytotoxicity and Biocompatibility

Synthesis and Characterization of Silver-Coated Polymeric Scaffolds for Bone Tissue Engineering: Antibacterial and In Vitro Evaluation of Cytotoxicity and Biocompatibility

Synthesis of Silver-Coated Bioactive Nanocomposite Scaffolds Based on Grafted Beta-Glucan/Hydroxyapatite via Freeze-Drying Method: Anti-Microbial and Biocompatibility Evaluation for Bone Tissue Engineering

Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study

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