Synthesis and characterization of bile <scp>acid‐based</scp> polymeric micelle as a drug carrier for doxorubicin

Altınkök, Çağatay; Açık, Gökhan; Karabulut, Ferhat; Çiftçi, Mustafa; Taşdelen, Mehmet Atilla; Dağ, Aydan

doi:10.1002/pat.5478

Cited by 10 publications

(7 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was left in the mixture overnight at 300 rpm. The next day, the unloaded drug and DMSO were removed by dialysis (MWCO: 3500) method . The mixture was stirred overnight at rt.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent

Zengin Kurt,

Öztürk Civelek,

Çakmak

et al. 2024

J. Med. Chem.

Self Cite

View full text Add to dashboard Cite

Sorafenib, a multiple kinase inhibitor, is widely used as a first-line treatment for hepatocellular carcinoma. However, there is a need for more effective alternatives when sorafenib proves insufficient. In this study, we aimed to design a structure that surpasses sorafenib's efficacy, leading us to synthesize sorafenib− ruthenium complexes for the first time and investigate their properties. Our results indicate that the sorafenib−ruthenium complexes exhibit superior epidermal growth factor receptor (EGFR) inhibition compared to sorafenib alone. Interestingly, among these complexes, Ru3S demonstrated high activity against various cancer cell lines including sorafenib-resistant HepG2 cells while exhibiting significantly lower cytotoxicity than sorafenib in healthy cell lines. Further evaluation of cell cycle, cell apoptosis, and antiangiogenic effects, molecular docking, and molecular dynamics studies revealed that Ru3S holds great potential as a drug candidate. Additionally, when free Ru3S was encapsulated into polymeric micelles M1, enhanced cytotoxicity on HepG2 cells was observed. Collectively, these findings position Ru3S as a promising candidate for EGFR inhibition and warrant further exploration for drug development purposes.

show abstract

“…It was left in the mixture overnight at 300 rpm. The next day, the unloaded drug and DMSO were removed by dialysis (MWCO: 3500) method . The mixture was stirred overnight at rt.…”

Section: Resultsmentioning

confidence: 99%

“…The next day, the unloaded drug and DMSO were removed by dialysis (MWCO: 3500) method. 34 The mixture was stirred overnight at rt. A similar procedure was repeated to obtain Ru4S -loaded polymeric micelles.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent

Zengin Kurt,

Öztürk Civelek,

Çakmak

et al. 2024

J. Med. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The PTX amount of micelles was determined using the obtained calibration curve. DLC and EE were calculated by using the equations below; 44 %DLC = (amount of drug loaded to micelles)/(amount of micelles)×100. %EE = (amount of drug loaded)/(amount of drug added)×100.…”

Section: Acs Applied Polymer Materialsmentioning

confidence: 99%

“…The PTX amount of micelles was determined using the obtained calibration curve. DLC and EE were calculated by using the equations below;…”

Section: Polymer Synthesismentioning

confidence: 99%

Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy

Gencoglu Katmerlikaya,

Cetin Ersen,

Dag

et al. 2024

ACS Appl. Polym. Mater.

Self Cite

View full text Add to dashboard Cite

Drug delivery systems for cancer therapy have been investigated to alter the properties of therapeutic molecules through covalent/noncovalent interactions, lessen harmful side effects, and enhance therapeutic outcomes. Nevertheless, it is important to sustain and enhance the targeting ability of drug delivery platforms, which are beneficial to the progress of precision medicine. In the present study, a series of protoporphyrin IX (PpIX)-containing glucose and fructosebased-glycoblock copolymers were synthesized via reversible addition− fragmentation chain transfer (RAFT) polymerization and click coupling reaction. Glycopolymeric photoactive micelles (GPMs) based on glycoblock copolymers (P(G/FMA l PpIX m -b-nBA n ); l = 25, m = 5, and n = 75) were prepared with antineoplastic drug loadings (paclitaxel, PTX) using a nanoprecipitation method. Glycosylated and fructosylated GPMs -GPM1−PTX and GPM2−PTX, respectively-with different diameters (127.02 and 121.20 nm) serve as suppliers of the reactive oxygen species (ROS) and PTX. This dual-engineered glyconanomedicine effectively induces synergistic interference against breast cancer owing to the dual-modal effect mediated by PpIX/PTX and glucose transporter (GLUT) targeting. Moreover, GPM1− PTX and GPM2−PTX overperformed with 4.0 and 1.8 times lower IC 50 values in cytotoxicity assays and had 3.59 and 3.55 times higher apoptosis/necrosis rates upon light irradiation when compared to that of combined free drugs formulation (PpIX + PTX) against breast cancer cells in vitro, respectively. Therefore, this work contributes to the photoactive glyconanomedicine platform in establishing the therapeutic benefit of the synergistic effect of GLUT-targeted photodynamic-chemotherapy, suggesting better therapy than monotherapy: free PpIX, and free PTX and combined free drugs formulation as well.

show abstract

“…6 As recorded, PMs can be applicable to use for the delivery of anticancer drugs. 22 Particularly, encapsulating hydrophobic anticancer drugs inside PMs can increase their aqueous solubility by a factor of up to 500, thus increasing their biological behavior and enhancing accumulation in the targeted site with fewer side effects on normal tissues. 3,23 Advances in polymer chemistry produce intelligent polymeric systems with greater regulation of the physicochemical characteristics, which is crucial for the precise delivery of anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Dual stimuli-responsive polymeric nanoparticles combining soluplus and chitosan for enhanced breast cancer targeting

Twal,

Jaber,

Al-Remawi

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin

Cited by 10 publications

References 47 publications

Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent

Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent

Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy

Dual stimuli-responsive polymeric nanoparticles combining soluplus and chitosan for enhanced breast cancer targeting

Contact Info

Product

Resources

About