Synthesis and characterization of biocompatible magnetic glyconanoparticles

Recent advances in biosensing using magnetic glyconanoparticles

“…Carbohydrate stabilizers containing carboxyl groups can also be used to obtain stable glycoMNPs. Kekkonen et al [21] synthesized magnetite nanoparticles coated with D-gluconic acid, lactobionic acid and Ficoll® (a sucrose-based polymer), showing that larger carbohydrate stabilizers such as Ficoll® produced nanoparticles with increased stability when compared with D-gluconic and lactobionic acid. Baccile et al [22] compared two one-pot synthetic routes for the preparation of magnetite nanoparticles stabilized by sophorolipids (natural functional glycolipids composed of two glucose units linked to an oleic acid moiety).…”

Glyconanomaterials: Emerging applications in biomedical research

“…In this context, carboxylic acid- and phosphate-functionalized carbohydrates are also effective in binding to iron oxide nanoparticles. For example, lactobionic acid, D-gluconic acid, Ficoll and carboxy-terminated glycolipids were used by Kekkonen et al and Baccile et al to stabilize MNPs [108, 109]. These MNPs showed increasing stability with increasing carbohydrate ligand size.…”

Lactobionic acid: A high value-added lactose derivative for food and pharmaceutical applications

“…Pharmaceutical Enhancement of solubility of macrolide antibiotics such as erythromycin and clarithromycin Anti-aging and keratinizing ingredient of skin care cosmetics Calcium supplementation Metal-chelating agent in organ preservation solutions Ingredient in chlorhexidine-based disinfectant Bio-surfactant in its fatty acid derivatives forms Inducer for cellulase production by Trichoderma reesei Functional molecule in the synthesis of polymeric nanoparticles for liver-specific drug deliver (Ahamed & Vermette, 2008;Frutos et al, 1997;Green et al, 2009;Jain & Jain, 2010;Playne & Crittenden, 2009;Van Hecke et al, 2011) Food Acidulant with a sweet taste Filler in cheese production Firming agent Calcium carrier in functional drinks Reduction of souring and ripening time for the production of cheese and yogurt Enhancement of flavors Improvement of bitter or sour taste of foods Preservation of aroma freshness Preparation of dairy products with reduced lactose content (Gerling, 1998;Merrill & Singh, 2009;Nakano et al, 2010;Nordkvist et al, 2007;Playne & Crittenden, 2009) Chemical Ion sequestrant in detergent solutions Biodegradable cobuilder in washing powder Anti-corrosive coatings Chiral selector for enantiomeric separation of basic drugs in capillary electrophoresis (clarithromycin lactobionate) Reactant for synthetic amides (Gerling, 1998;Yu et al, 2011) Nanotechnology Part of biocompatible scaffolds for tissue engineering Part of nanoplatforms for new bioimaging applications Ingredient of galactose-conjugated fluorescent nanoparticles for immunofluorescence assays (Chung et al, 2002;Kekkonen et al, 2009;Peng et al, 2007) volunteers periodically over two weeks (Tasic-Kostov et al, 2010). LBA could increase the synthesis of glycosaminoglycans in the skin, and it has been shown to enhance cell turnover in vitro (Briden & Green, 2005).…”