Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

Abstract

Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/HO/CoCl the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.

Synthesis and characterization of polypropylene‐graft‐poly(l‐lactide) copolymers by CuAAC click chemistry

“…The biodegradation behaviors of polymers are affected by number of factors, including functional groups that increase hydrophilicity or hydrophobicity, modulus of elasticity, molecular weight, size or density of polymer, changes in the crystalline and amorphous regions, degree of cross‐linking, glass transition temperature, presence of easily breakable bonds such as ester or amide, and presence of resistive carbon–carbon groups …”

Highlighting the usage of polymeric nanoparticles for the treatment of traumatic brain injury: A review study

“…Polyurethane nanoparticles can degrade hydrolytically or enzymatically depending on the chemistry of the particles and the environment (Hung et al 2009;Feng et al 2017;Aluri et al 2018;Pramanik et al 2018). Like PBCU nanoparticles, the chemistry to synthesize polyurethane nanoparticles is straight forward and flexible.…”

<p>Impacts of a Nano-Laponite Ceramic on Surface Performance, Apatite Mineralization, Cell Response, and Osseointegration of a Polyimide-Based Biocomposite</p>

“…4 In the past few decades, nondegradable polymers (NDPs), such as polyetheretherketone (PEEK), polyethylene (PE), polyamide (PA), polytetrafluoroethylene, polypropylene, and polyurethane, have been also widely applied for soft/hard-tissues repair, due to their atoxicity and biosafety in vivo. [5][6][7] Moreover, NDPs have attracted much attention for load-bearing bone repair, because of superior biocompatibility and mechanical properties and easy processing, as well as corrosion resistance. Importantly, elastic moduli of NDPs are close to that of human cortical bone, which decreases the stress-shielding effect compared with metallic implants.…”

“…Synthetic NDPs (eg, PA, PE, and PEEK) possess outstanding mechanical properties and machinability, as well as easy processing. [5][6][7] Therefore, in the past few decades, inorganic bioactive materials-NDP composites (eg, hydroxyapatite-PA, calcium silicate-PEEK, and bioglass-PE) have been investigated for their great potential for load-bearing bone repair. 16 Laponite (Lap), a synthetic layered silicate and bioactive material, has been developed as a new biomaterial for treatment of diseases and regenerative medicine, due to its biocompatibility.…”