Synthesis and characterization of bis-chelated nickel(II) complexes of the methylpyruvate Schiff bases of S-alkyldithiocarbazates and the X-ray crystal structure of the [Ni(ONSMe)2] complex

Synthesis, characterization and X-ray crystal structures of the bis?ligand zinc(II) and cadmium(II) complexes of the methylpyruvate Schiff base of S-methyldithiocarbazate

“…Both complexes have a distorted octahedral geometry with two ligands in a meridional configuration (the two azomethine nitrogen atoms are trans and the two sulfur atoms are cis to each other). Similar meridional arrangements of ligands have also been observed in all bis-ligand metal complexes of tridentate thiosemicarbazone [16,17,41] and dithiocarbazate ligands [6,13]. In both complexes the ligands are coordinated in their iminothiolate forms.…”

“…In our previous studies [12,13] it was also observed that, in the presence of nickel(II) and copper(II) ions, the methylpyruvate Schiff base of S-methyldithiocarbazate (Hmpsme) quickly converted into its thiol tautomeric form yielding complexes of the deprotonated thiolate form.…”

“…Transition metal complexes of hard-soft nitrogen-sulfur chelating agents such as Schiff bases derived from S-alkyl-and S-aryl esters of dithiocarbazic acid [1][2][3][4][5][6][7][8][9][10][11][12][13] and thiosemicarbazones [14][15][16][17][18][19][20][21][22][23][24] have been the subject of considerable study because of their interesting physicochemical properties [25][26][27][28][29][30] and potentially useful chemotherapeutic activity [1,9,10,[17][18][19][20]24]. The methylpyruvate Schiff base of S-methyldithiocarbazate (Hmpsme; Figure 1a) has been found to exhibit promising anti-leukemia properties [31].…”

Synthesis, Characterization and Biological Activities of Organotin (IV) Methylcyclohexyldithiocarbamate Compounds

“…The cell was cultured in RPMI-1640 (Sigma) medium supplemented with 10% fetal calf serum (Flow Lab). Solutions of different concentrations were prepared from stock solutions (10 mg cM ) by serial dilution in RPMI-1640 to give a volume of 100 µL in each well of a microtiter plate as described by Ali et al (1999). Each well was filled with 100 µL of cell suspension in a complete growth medium (CGM) at 1-2×10 5 cells cm…”

Synthesis, spectroscopic, thermal and anti-microbial studies of transition metal complexes of hydrazone derived from 4,6-diacetylresorcinol and S-methyldithiocarbazate

“…The presence of hard nitrogen and soft sulfur donor atoms in the backbones of these ligands enable them to react readily with transition metal ions yielding colored stable metal complexes [8][9][10][11][12]. Moreover, these complexes are potentially biologically active and exhibit antifungal, antimicrobial, antimalarial, antitumoral, antiviral, and antioxidant activities [13][14][15][16][17][18][19][20].…”