Synthesis and Characterization of Carboxymethyl Chitosan Nanogels for Swelling Studies and Antimicrobial Activity

Farag, Reem K.; Mohamed, Riham R.

doi:10.3390/molecules18010190

Cited by 119 publications

(50 citation statements)

References 36 publications

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“…However, the application of chitosan as an injectable scaffold is limited due to the presence of strong intermolecular hydrogen bonding, making it insoluble in physiological solvents . Carboxymethyl chitosan (CMCS) is a derivative that has significant advantages over chitosan and can be used in controlled drug delivery systems . Because it bears amine and anionic carboxyl groups, the swelling and drug permeation and release properties of a carboxymethyl chitosan matrix can be controlled by adjusting the pH.…”

Section: Introductionmentioning

confidence: 99%

pH‐sensitive hydrogel based on carboxymethyl chitosan/sodium alginate and its application for drug delivery

Xie

Tian

et al. 2018

J of Applied Polymer Sci

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Carboxymethyl chitosan sodium salt (CMCS)/sodium alginate (SA), a pH‐sensitive hydrogel composed of CMCS and SA crosslinked by 1‐ethyl‐3‐(3‐dimethyl aminopropyl) carbodiimide (EDC) and N‐hydroxysuccinimide, has been evaluated in vitro as a potential carrier for protein drug delivery of bovine serum albumin (BSA). The crosslinked structures, pore morphologies, and mechanical properties of the composite CMCS/SA hydrogel at different pH have been characterized by Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and dynamic mechanical analysis (DMA). The swelling behavior of the prepared hydrogel was assessed at different pH values, 1.2, 4.0, 6.86, 7.4, and 9.0. The in vitro slow release ability of the CMCS/SA hydrogel was assessed at 37°C and pH 1.2 or pH 7.4 to simulate gastrointestinal and mouth environments in vivo. The efficiency was found to be greater than 90% at pH 7.4. The composite CMCS/SA hydrogel showed no cytotoxic effect toward L‐929 cells according to the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide test. These findings demonstrate that the composite hydrogel has promising potential for drug delivery. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46911.

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Section: Introductionmentioning

confidence: 99%

pH‐sensitive hydrogel based on carboxymethyl chitosan/sodium alginate and its application for drug delivery

Xie

Tian

et al. 2018

J of Applied Polymer Sci

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“…Furthermore, peaks were observed at 1069 cm −1 specific for the secondary hydroxyl groups (characteristic peak of -CH, -OH in cyclic alcohols, and C-O stretch). 17 For PEG, the stretching of C-O ether groups at 950-1106 cm −1 was shown. 18,19 Also alkyl (R-CH 2 ) stretching modes at 2872 cm −1 were observed.…”

Section: Ftir Analyses Of Gel Portionmentioning

confidence: 99%

Synthesis and Characterization of Cross‐linked Polyethylene Glycol/Carboxymethyl Chitosan Hydrogels

2014

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ABSTRACT:Cross-linked hydrogels of polyethylene glycol (PEG) and carboxymethyl chitosan (CMCh) were synthesized using a blending technique. Several analysis tools were used to characterize the physical and thermal properties of CMCh/PEG hydrogels, namely, Fourier transform infrared, scanning electron microscope, X-ray diffraction, and thermogravimetric analysis. Some applications were carried out for the prepared cross-linked hydrogels; swelling behavior of the CMCh/PEG hydrogels was studied in different buffered solutions and different salt solutions. Metal ions uptake was studied for CMCh/PEG hydrogels. The biological activity of CMCh/PEG towards Escherichia coli has been examined in this study. C 2014 Wiley Periodicals, Inc. Adv Polym Technol 2014, 0, 21479; View this article online at wileyonlinelibrary.com.

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“…The degree of substitution of CMC was determined to be 0.75 according to the method described in the literature. 35,36…”

Section: Preparation Of Carboxymethyl Chitosan (Cmc)mentioning

confidence: 99%

T7 bacteriophage induced changes of gold nanoparticle morphology: biopolymer capped gold nanoparticles as versatile probes for sensitive plasmonic biosensors

Kannan

Łoś

et al. 2014

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The morphological changes of gold nanoparticles induced by T7 virus (bacteriophage) and the determination of its femtomolar concentration by a plasmonic method are presented. Carboxymethyl chitosan capped gold nanoparticles (CMC-AuNPs) are used as plasmonic probes and are synthesized by a simple one pot wet chemical method. HR-TEM images show that the spherical structure of the CMC-AuNPs is changed into chain-like nanostructures after the addition of T7 virus due to the strong coordination of CMC-AuNPs with T7. Since T7 capsids comprise a repeating motif of capsomers built from proteins that bind to the acid groups of chitosan, the conjugation of carboxymethyl chitosan-linked AuNPs with T7 virions enables colorimetric biosensing detection. The absorbance intensity (∼610 nm) increases in the concentration range of T7 from 2 × 10(-15) M to 2 × 10(-13) M and the detection limit is found to be 2 × 10(-15) M (2 fM). The present work demonstrates eco-friendly biopolymer stabilized AuNPs as potential nanomaterials for biosensing of viruses. Our method is very simple, low cost, selective and highly sensitive, and provides new insight into virus induced chain-like morphology of AuNPs.

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Synthesis and Characterization of Carboxymethyl Chitosan Nanogels for Swelling Studies and Antimicrobial Activity

Cited by 119 publications

References 36 publications

pH‐sensitive hydrogel based on carboxymethyl chitosan/sodium alginate and its application for drug delivery

pH‐sensitive hydrogel based on carboxymethyl chitosan/sodium alginate and its application for drug delivery

Synthesis and Characterization of Cross‐linked Polyethylene Glycol/Carboxymethyl Chitosan Hydrogels

T7 bacteriophage induced changes of gold nanoparticle morphology: biopolymer capped gold nanoparticles as versatile probes for sensitive plasmonic biosensors

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