Synthesis and Characterization of Cationic Poly(N-[3-Hexyldimethyl-Aminopropyl] Methacrylamide Bromide) Water-Soluble Polymer

Abstract

Water-soluble polymer, cationic poly(N-[3-hexyldimethyl-aminopropyl]methacrylamide bromide) (PHDAPMAA), is synthesized by radical polymerization and studied in terms of its solubility, viscosity, surface tension and conductivity. Viscometry and surface tension measurements confirmed that intramolecular hydrophobic microdomains were formed by the pendent alkyl chains. Conductivity of cationic polymer in aqueous solution was determined. Variation of conductivity versus concentration in investigated system exhibits a typical polyelectrolyte behaviour.

Toward Next-Generation Biohybrid Catalyst Design: Influence of Degree of Polymerization on Enzyme Activity

“…The active site of TL lipase is covered by an amphiphilic lid . In aqueous media, the lid is closed, but in hydrophobic environments the lid is open, leading to an increase in activity. , We hypothesized that an application of interfacial surface pressure via the grafting of an amphiphilic polymer (e.g., pDMAPA) ligated to the TL surface may accomplish enzyme activation via lid opening, while also preventing denaturation in organic media by inhibiting aggregation and denaturation. Furthermore, the polymer shell would also promote dispersal in both aqueous and organic solvents …”

Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating

“…The two monomers selected for the creation of potential polymer brush-based antiviral coatings were N -[3-decyldimethyl-aminopropyl]­methacrylamide bromide ( A10 ) and carboxybetaine methacrylate ( CBMA ). The A10 monomer was synthesized via the quaternization reaction of N -[3-(dimethylamino)­propyl]­methacrylamide and 1-bromodecane according to a slight modification of a previously reported procedure (see the Experimental Section for details) . The antiviral polymer brush-based coatings were created in four steps starting from bare silicon surfaces according to a modified previously published protocol (Scheme ).…”

“…The A10 monomer was synthesized via the quaternization reaction of N -[3-(dimethylamino)propyl]methacrylamide and 1-bromodecane according to a slight modification of a previously reported procedure (see the Experimental Section for details). 54 The antiviral polymer brush-based coatings were created in four steps starting from bare silicon surfaces according to a modified previously published protocol ( Scheme 2 ). 21 , 47 The silicon surfaces were plasma cleaned for 5 min, and subsequently, (3-aminopropyl)triethoxysilane (APTES) was immobilized.…”

“…Monomer A10 was synthesized via a quaternization reaction of N -[3-(dimethylamino)­propyl]­methacrylamide and 1-bromodecane, according to a slight modification of a previously reported procedure . In a round-bottom flask with a septum, 10 mL of acetonitrile was added to a mixture of N -[3-(dimethylamino)­propyl]­methacrylamide (0.03 mol, 5.10 g, 4.79 mL), 1-bromodecane (0.03 mol, 6.64 g), and a small amount of an inhibitor (hydroquinone).…”

“…Monomer A10 was synthesized via a quaternization reaction of N -[3-(dimethylamino)propyl]methacrylamide and 1-bromodecane, according to a slight modification of a previously reported procedure. 54 In a round-bottom flask with a septum, 10 mL of acetonitrile was added to a mixture of N -[3-(dimethylamino)propyl]methacrylamide (0.03 mol, 5.10 g, 4.79 mL), 1-bromodecane (0.03 mol, 6.64 g), and a small amount of an inhibitor (hydroquinone). The flask was sealed with a septum under argon and heated at 50 °C under magnetic stirring for 24 h. Upon addition of 250 mL of dry ethyl ether to the reaction mixture, N -[3-(decyldimethyl)-aminopropyl]methacrylamide bromide ( A10 ) was isolated as white crystals and dried (7.00 g, yield 60%).…”