Synthesis and characterization of chitosan nanoparticles containing teicoplanin using sol–gel

Kahdestani, Shafiq Ahmad; Shahriari, Mehrnoosh Hasan; Abdouss, Majid

doi:10.1007/s00289-020-03134-2

Cited by 58 publications

(30 citation statements)

References 20 publications

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“…Besides, the CHS NPs showed a bigger particle size. These results were in agreement with previous studies (Feyzioglu & Tornuk, 2016;Kahdestani, Shahriari, & Abdouss, 2020).…”

Section: Sem and Edx Analysissupporting

confidence: 94%

Preparation of Allantoin Loaded Chitosan Nanoparticles and Influence of Molecular Weight of Chitosan on Drug Release

Ulu

2020

İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi

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In this study, allantoin-loaded chitosan nanoparticles were prepared and the effect of molecular weights (low, medium, and high) of chitosan was investigated on the release of allantoin. The allantoin-loaded chitosan nanoparticles were characterized by various methods. The morphology, size, zeta potential, and loading efficiency were affected by the molecular weight of chitosan. The results displayed that the average hydrodynamic diameter of chitosan nanoparticles was in the range of 427-768 nm and the zeta potential values from 5.97 to 5.12 mV was obtained. The allantoin release from chitosan nanoparticles reached the plateau level in 96 hours. Cumulative allantoin release values of low, medium, and high molecular mass chitosan nanoparticles were determined as 43%, 30%, and 27%, respectively. According to the results, the molecular weight of chitosan influenced on allantoin release.

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“…Besides, the CHS NPs showed a bigger particle size. These results were in agreement with previous studies (Feyzioglu & Tornuk, 2016;Kahdestani, Shahriari, & Abdouss, 2020).…”

Section: Sem and Edx Analysissupporting

confidence: 94%

Preparation of Allantoin Loaded Chitosan Nanoparticles and Influence of Molecular Weight of Chitosan on Drug Release

Ulu

2020

İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi

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“…In another study, a drug delivery system based on chitosan nanoparticles acquired by ionotropic gelation, loaded with teicoplanin, and incorporated in tripolyphosphate (TPP) was investigated. No interaction between teicoplanin and chitosan was evidenced but an increase in nanochitosan size caused by the drug was confirmed [ 181 ].…”

Section: Deposition Techniques For Polymeric Thin Films Fabricationmentioning

confidence: 99%

Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

2021

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The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.

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“…Prominent peaks of the degrees 22 is seen in all three samples, but other peaks are shown only by increasing the amount of starch. This indicates the entry of polyacrylamide‐acrylic acid into the starch plates during the polymerization process, which shifts the reflection perpendicular to the base plate to larger angles, which is the sign of the formation of the compound 27 …”

Section: Resultsmentioning

confidence: 97%

Radiation initiated synthesis, characterization, and swelling behavior of poly (acrylic acid‐co‐acrylamide)/starch grafted hydrogel

Ebrahimi

2021

J of Applied Polymer Sci

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The powerful waves of ultrasound are used in polymerization reactions in the absence of initiator. In the present research, the hydrogel was obtained by water‐soluble acrylic monomers, starch, and the crosslinking agent of methylene bis acrylamide dissolved in water/glycerol dual. The hydrogel is formed by these waves only in viscous environments such as glycerol, heat, or initiator is not required. In the presence of ultrasound, the time of product formation is reduced to a few minutes. Moreover, the resulting hydrogels have more uniform microscopic structure and are more swollen. The structure of the grafted hydrogel was examined meanwhile the hydrogel swelling in three environments of pure water, saltwater, and under pressure was measured. It was found that the grafted hydrogel has double swelling rate in the pure. Also, after loading the ciprofloxacin into the synthesized hydrogel, this drug is released 99% in initial 20 min. 0.1 g starch in 1.5 g acrylic hydrogel has the most drug release. The high swelling capacity in the pH ranges of 5–9 shows the extension of drug application in acidic or alkaline environments, and also after several using the gel and the capacity of water absorbency, which was about 70% of its initial water, indicates the perfect reusability capacity of the gel.

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Synthesis and characterization of chitosan nanoparticles containing teicoplanin using sol–gel

Cited by 58 publications

References 20 publications

Preparation of Allantoin Loaded Chitosan Nanoparticles and Influence of Molecular Weight of Chitosan on Drug Release

Preparation of Allantoin Loaded Chitosan Nanoparticles and Influence of Molecular Weight of Chitosan on Drug Release

Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

Radiation initiated synthesis, characterization, and swelling behavior of poly (acrylic acid‐co‐acrylamide)/starch grafted hydrogel

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