Synthesis and characterization of chitosan nanoparticles decorated with folate and loaded with dasatinib for targeting folate receptors in cancer cells

Kumbhar, Smita T.; Patil, Ravikant Yashwantrao; Bhatia, Manish S.; Choudhari, Prafulla B.; Gaikwad, Vinod Limbraj

doi:10.1016/j.onano.2022.100043

Cited by 9 publications

(1 citation statement)

References 17 publications

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“…Active targeting is a key feature of nanomedicine in cancer therapy for enhancing drug reach-ability to the intended region, which leads to therapeutic success and reduces adverse effects [16,[106][107][108][109][110]. Various ligands may be linked to the surface of LPHNPs due to their structural specificity and multi-functionality, allowing for therapeutic targeting of tumorous sites [111][112][113][114][115][116] Antibodies [117,118], peptides [119,120] folate [121][122][123][124], transferrin [125][126][127][128] and aptamers [129][130][131][132][133][134] are some of the ligands employed for targeting LPHNPs. This nanocarrier system may also be proved effective for the oral route of drug administration against life-threatening diseases [135][136][137].…”

Section: Advantages Of Lphnpsmentioning

confidence: 99%

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Gajbhiye,

Salve,

Narwade

et al. 2023

Mol Cancer

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Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug therapy. But presently, detailed investigations have revealed their flaws as drug delivery carriers. Lipid polymer hybrid nanoparticles (LPHNPs) are advanced core–shell nanoconstructs with a polymeric core region enclosed by a lipidic layer, presumed to be derived from both liposomes and polymeric nanounits. This unique concept is of utmost importance as a combinable drug delivery platform in oncology due to its dual structured character. To add advantage and restrict one’s limitation by other, LPHNPs have been designed so to gain number of advantages such as stability, high loading of cargo, increased biocompatibility, rate-limiting controlled release, and elevated drug half-lives as well as therapeutic effectiveness while minimizing their drawbacks. The outer shell, in particular, can be functionalized in a variety of ways with stimuli-responsive moieties and ligands to provide intelligent holding and for active targeting of antineoplastic medicines, transport of genes, and theragnostic. This review comprehensively provides insight into recent substantial advancements in developing strategies for treating various cancer using LPHNPs. The bioactivity assessment factors have also been highlighted with a discussion of LPHNPs future clinical prospects. Graphical Abstract

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Section: Advantages Of Lphnpsmentioning

confidence: 99%

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Gajbhiye,

Salve,

Narwade

et al. 2023

Mol Cancer

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Chitosan Nanoparticles: Drug Delivery Carriers in Cancer Therapy

Joy,

Sathya Seeli,

Prabaharan

2024

Advances in Polymer Science

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Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for augmenting its hypoglycemic activity: in vitro-in vivo assessment study

Elmoghayer,

Saleh,

Abu Hashim

2023

Drug Deliv. and Transl. Res.

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Hesperidin (Hsd), a bioactive phytomedicine, experienced an antidiabetic activity versus both Type 1 and Type 2 Diabetes mellitus. However, its intrinsic poor solubility and bioavailability is a key challenging obstacle reflecting its oral delivery. From such perspective, the purpose of the current study was to prepare and evaluate Hsd-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles (Hsd/CD/CS NPs) for improving the hypoglycemic activity of the orally administered Hsd. Hsd was first complexed with sulfobutylether-β-cyclodextrin (SBE-β-CD) and the complex (CX) was found to be formed with percent complexation efficiency and percent process efficiency of 50.53 ± 1.46 and 84.52 ± 3.16%, respectively. Also, solid state characterization of the complex ensured the inclusion of Hsd inside the cavity of SBE-β-CD. Then, Hsd/CD/CS NPs were prepared using the ionic gelation technique. The prepared NPs were fully characterized to select the most promising one (F1) with a homogenous particle size of 455.7 ± 9.04 nm, a positive zeta potential of + 32.28 ± 1.12 mV, and an entrapment efficiency of 77.46 ± 0.39%. The optimal formula (F1) was subjected to further investigation of in vitro release, ex vivo intestinal permeation, stability, cytotoxicity, and in vivo hypoglycemic activity. The results of the release and permeation studies of F1 manifested a modulated pattern between Hsd and CX. The preferential stability of F1 was observed at 4 ± 1 °C. Also, the biocompatibility of F1 with oral epithelial cell line (OEC) was retained up to a concentration of 100 µg/mL. After oral administration of F1, a noteworthy synergistic hypoglycemic effect was recorded with decreased blood glucose level until the end of the experiment. In conclusion, Hsd/CD/CS NPs could be regarded as a hopeful oral delivery system of Hsd with enhanced antidiabetic activity. Graphical Abstract

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Synthesis and characterization of chitosan nanoparticles decorated with folate and loaded with dasatinib for targeting folate receptors in cancer cells

Cited by 9 publications

References 17 publications

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Chitosan Nanoparticles: Drug Delivery Carriers in Cancer Therapy

Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for augmenting its hypoglycemic activity: in vitro-in vivo assessment study

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