Synthesis and characterization of chitosan-based pH-sensitive semi-interpenetrating network microspheres for controlled release of diclofenac sodium

Ahmed, Asmaa; Naik, H.S. Bhojya; Sherigara, B. S.

doi:10.1016/j.carres.2009.01.011

Cited by 67 publications

(13 citation statements)

References 35 publications

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“…We also characterized the swelling behavior and degradation profile of the hydrogels by examining the wet weight remaining ratios that allows us to examine the change of the same sample over time . In our study, different ratios of Ch to LA significantly affected swelling, shrinking, and enzymatic degradation of the hydrogels.…”

Section: Discussionmentioning

confidence: 97%

In vitro evaluation of photo‐crosslinkable chitosan‐lactide hydrogels for bone tissue engineering

et al. 2014

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Here we report the development and characterization of novel photo-crosslinkable chitosan-lactide (Ch-LA) hydrogels for bone tissue engineering. We synthesized the hydrogels based on Ch, LA, and methacrylic anhydride (MA), and examined their chemical structures, degradation rates, compressive moduli, and protein release kinetics. We also evaluated the cytotoxicity of the hydrogels and delivery efficacy of bone morphogenetic protein-2 (BMP-2) on osteoblast differentiation and mineralization using W-20-17 preosteoblast mouse bone marrow stromal cells and C2C12 mouse myoblast cells. NMR and FTIR revealed that the hydrogels were formed via amidation and esterification between Ch and LA, and methacrylation for photo-crosslinkable networks. Addition of a hydrophobic LA moiety to a hydrophilic Ch chain increased swellability, softness, and degradation rate of the photo-crosslinkable Ch-LA hydrogels. Changes in Ch/LA ratio and UV exposure time significantly affected compressive modulus and protein release kinetics. The photo-crosslinkable Ch-LA hydrogels were not cytotoxic regardless of the composition and UV crosslinking time. Higher alkaline phosphatase activities of both W-20-17 and C2C12 cells were observed in the less-crosslinked hydrogels at day 5. Mineralization was enhanced by sustained BMP-2 release from the hydrogels, but was cell type dependent. This photo-crosslinkable Ch-LA hydrogel is a promising carrier for growth factors.

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Section: Discussionmentioning

confidence: 97%

In vitro evaluation of photo‐crosslinkable chitosan‐lactide hydrogels for bone tissue engineering

et al. 2014

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“…Various studies have been conducted to develop semi‐IPN hydrogels based on CS to obtain materials with pH/temperature sensitivity and controlled degradability for drug delivery applications . Better antibacterial activity, coupled with high mechanical strength, may also be provided by semi‐IPN CS hydrogels for targeted wound dressing applications .…”

Section: Interpenetrating Polymer Network (Ipn) Cs Hydrogelsmentioning

confidence: 99%

“…Nevertheless, fully IPNs provide interesting mechanical properties and sophisticated networks for biomedical applications. Some studies reported IPNs composed of gelatin and CS where CS was crosslinked with classic common crosslinkers such as glutaraldehyde or genipin . CS reinforced the weak mechanical properties of the physically crosslinked gelatin network and prevented its rapid dissolution in aqueous media.…”

Section: Interpenetrating Polymer Network (Ipn) Cs Hydrogelsmentioning

confidence: 99%

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Racine

Texier

Auzély‐Velty

2017

Polymer International

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Chitosan (CS) has received much attention as a functional biopolymer for designing various hydrogels for biomedical applications. This review provides an overview of the different types of CS-based hydrogels, the approaches that can be used to fabricate hydrogel matrices with specific features and their applications in controlled drug delivery and tissue engineering. Emphasis is laid on the recent design concepts of hybrid hydrogels based on mixtures of CS and natural or synthetic polymers, interpenetrating polymer networks as well as composite hydrogels prepared by embedding nanoparticles into CS matrices.

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“…This strategy will offer a feasible means for delivering the drug in a sustained manner with lower side effects. In drug delivery systems, DIC has been used by various drug carriers such as poly(ethylene oxide) and hydroxypropylmethylcellulose [17], sodium alginate [18], Zn-Al-NO 3 -layered double hydroxides [19], and chitosan [20].…”

Section: Introductionmentioning

confidence: 99%

Controlled release of Diclofenac, an anti-inflammatory drug by nanocompositing with layered zinc hydroxide

Nabipour

Sadr

2015

J Porous Mater

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The anti-inflammatory drug, Diclofenac (DIC) anion, was intercalated into the layered zinc hydroxide (LZH) by ion-exchange method. Then, the DIC-LZH/ Chitosan nanocomposite was prepared by coating of Chitosan on DIC-LZH. LZH intercalated with DIC was successfully encapsulated into Chitosan by precipitation method. The structures of the obtained products were studied by powder X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and thermal analysis. The XRD patterns and FTIR analyses showed that the DIC was successfully intercalated into the LZH interlayer space with an average basal spacing of 29.42 Å . Thermal analysis studies confirmed that the thermal stability of DIC was enhanced after intercalation into LZH. In addition, drug release behaviors in vitro of DIC from DIC-LZH and DIC-LZH/Chitosan nanocomposites were observed in phosphate buffer solution under the conditions of pH 4.8 and 7.4, respectively.

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Synthesis and characterization of chitosan-based pH-sensitive semi-interpenetrating network microspheres for controlled release of diclofenac sodium

Cited by 67 publications

References 35 publications

In vitro evaluation of photo‐crosslinkable chitosan‐lactide hydrogels for bone tissue engineering

In vitro evaluation of photo‐crosslinkable chitosan‐lactide hydrogels for bone tissue engineering

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Controlled release of Diclofenac, an anti-inflammatory drug by nanocompositing with layered zinc hydroxide

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