Synthesis and characterization of chitosan–poly(acrylic acid) nanoparticles

Hu, Yong; Jiang, Xiqun; Ding, Yin; Ge, Haixiong; Yuan, Yuyan; Yang, Changzheng

doi:10.1016/s0142-9612(02)00071-6

Cited by 485 publications

(303 citation statements)

References 28 publications

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“…The very intense characteristic band at 1560 cm −1 is due to the C(O asymmetric stretching of the carboxylate anion from poly(AA) grafted onto M3 and M4 chitosan membranes. This is reconfirmed by other sharp peak at 1405 cm −1 , which is related to the symmetric stretching mode of the carboxylate anion (Hu et al, 2002;Mahdavinia et al, 2004). The salt form of the free carboxylic group is expected since the membranes were neutralized with sodium hydroxide solution to remove them from the plates.…”

Section: Resultsmentioning

confidence: 69%

Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

Santos

Coelho

Ferreira

et al. 2006

International Journal of Pharmaceutics

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Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thrombogenicity and haemolytic activity of these membranes were evaluated. Chitosan-graft-AA-graft-HEMA showed to be the best matrix for drug delivery systems than chitosan-graft-AA because it retains good swelling properties, but the content in HEMA has improved cytocompatibility, hemocompatibility and thrombogenic character.

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Section: Resultsmentioning

confidence: 69%

Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

Santos

Coelho

Ferreira

et al. 2006

International Journal of Pharmaceutics

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“…The direct acid-base reaction between COOH and NH 2 groups leading to ionic bonds is also very probable [35].…”

Section: Discussion Characteristics Of Obtained Materials By Uv-vis mentioning

confidence: 99%

Preparation and characteristics of nanosilver composite based on chitosan-graft-acrylic acid copolymer

2015

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The aim of this work was to prepare and characterize the novel antibacterial nanocomposites based on chitosan, grafted acrylic acid and silver nanoparticles (AgNPs). Chitosan has been functionalised by chemical reaction with acrylic acid, and then mixed with silver nanoparticles (AgNPs). AgNPs have been obtained formerly by chemical reduction of silver nitrate in the presence of mercaptosuccinic acid as a nanoparticles stabilizer. Structure and properties of obtained nanocomposite have been characterised by UV-vis, FTIR and 13C-NMR spectroscopy. The morphology of silver chitosang-acrylic acid nanocomposite has been studied by electron microscopy (SEM/EDX and HR-TEM). Thermal stability has been investigated by thermogravimetric analysis. The grafted chitosan contained 70.9 % wt acrylic acid, as determined by gravimetric method. It was found that modified chitosan forms water-insoluble gel with lower thermal resistance than pure chitosan. However, the difference between thermal properties of grafted chitosan and its nanocomposite with AgNPs is negligible. The grafting reaction mechanism has been discussed in detail on the basis of the obtained results and current literature data.

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“…In this work, a non-toxic hydrophilic polymer, poly(acrylic acid) (PAA), with a low molecular weight, was employed as the crosslinker due to its chain mobility and carboxyl groups that react with the hydroxyl groups in PVA to form an ester [24,25]. Similar to PVA, PAA also displays excellent biocompatibility and has been used in applications such as sitespecific drug delivery systems [26,27], wound dressing materials [28] and partially degradable bone cements [29]. It has also been used in conjunction with PVA to form hydrogel fibres where the degree of swelling can be easily controlled by the degree of crosslinking [30].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Porous poly(vinyl alcohol)/sepiolite bone scaffolds: Preparation, structure and mechanical properties

Killeen

Frydrych

Chen

2012

Materials Science and Engineering: C

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Porous poly(vinyl alcohol) (PVA)/sepiolite nanocomposite scaffolds containing 0-10wt.% sepiolite were prepared by freeze-drying and thermally crosslinked with poly(arylic acid).The microstructure of the obtained scaffolds was characterised by scanning electron microscopy and micro computer tomography, which showed a ribbon and ladder like interconnected structure. The incorporation of sepiolite increased the mean pore size and porosity of the PVA scaffold as well as the degree of anisotropy due to its fibrous structure.The tensile strength, modulus and energy at break of the PVA solid material that constructed the scaffold were found to improve with additions of sepiolite by up to 104%, 331% and 22% for 6wt.% clay. Such enhancements were attributed to the strong interactions between the PVA and sepiolite, the good dispersion of sepiolite nanofibres in the matrix and the intrinsic properties of the nanofibres. However, the tensile properties of the PVA scaffold deteriorated in the presence of sepiolite because of the higher porosity, pore size and degree of anisotropy.The PVA/sepiolite nanocomposite scaffold containing 6wt.% sepiolite was characterized by an interconnected structure, a porosity of 89.5% and a mean pore size of 79μm and exhibited a tensile strength of 0.44MPa and modulus of 14.9MPa, which demonstrates potential for this type of materials to be further developed as bone scaffolds.

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Synthesis and characterization of chitosan–poly(acrylic acid) nanoparticles

Cited by 485 publications

References 28 publications

Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

Preparation and characteristics of nanosilver composite based on chitosan-graft-acrylic acid copolymer

Porous poly(vinyl alcohol)/sepiolite bone scaffolds: Preparation, structure and mechanical properties

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