Synthesis and characterization of cobalt ferrites nanoparticles with cytotoxic and antimicrobial properties

Abstract

Recently, the application of nanotechnology in food sector and the agriculture attract the attention compared to its biomedical application. The aims of the current study was to synthesize and characterize cobalt ferrites nanoparticles [(CoFe2O4) NPs] by combustion method employing glycine as fuels and to evaluate their antimicrobial against pathogenic bacteria and fungi and anti cancer properties against MCF-7 breast cancer cells line. The results indicated that the particles size of the synthesized (CoFe2O4) NPs was 40 nm. These (CoFe2O4) NPs showed potential antibacterial properties against Gram-negative bacteria (Escherichia coli, Salmonella typhi) and Gram-positive bacteria (Staphylococcus aureus, Bacillus cereus) as well as the pathogenic fungi (Aspergillus flavus and Aspergillus ochraceus) in a dose dependent manner with maximum concentration of 1.8 mg/ml. (CoFe2O4) NPs also showed weak antiradical but have cytotoxic effects against MCF-7 breast cancer cells line and succeeded to decrease the cell viability at a concentration of 2 mg/ml. It could be concluded that (CoFe2O4) NPs is a promise candidate as antimicrobial and anticancer agent for food sector and medical application.

Antibacterial and Antifungal Activity of Novel Synthesized Neodymium-Substituted Cobalt Ferrite Nanoparticles for Biomedical Application

“…Cobalt ferrite has been an interesting field in the past few decades for its unique and controllable characteristics and its potential use in biomedical applications, such as enhanced drug stability/solubility, and reduced side effects [17][18][19][20][21], Amiri andShokrollahi, 2013, Hathout et al, 2017. Metal combination with cobalt ferrite could obtain new complex materials with improved bioactivity, and such experiments on the antimicrobial aspect of ferrites have achieved success [22,23].…”

Evaluation the safety and synergistic effect of NiFe2O4 nanoparticles with antibiotic against Pseudomonas aeruginosa

“…The small size and the high surface to volume ratio. Large surface area enhances the interaction between the nanoparticles and the microbes to carry out a broad range of probable antimicrobial activities (17). The lag phase of the growth cycle may be prolonged and the generation time of the organisms increased because of the nanoparticle binding to membranes of microorganisms (18).…”

Mentha suaveolens Leaves Extract‐Mediated Synthesis of CoO@TiO2 and Fe2O3@TiO2 Core/Shell Nanoparticles with Synergistic Antimicrobial and Antioxidant Activities

“…Additionally, titanium nanoparticles have been shown to possess anti‐inflammatory and antioxidant properties, suggesting their potential for treating inflammatory diseases and oxidative stress‐related disorders [47] . Cobalt nanoparticles have also been shown to exhibit various biological activities, including antibacterial, antifungal, and antitumor properties [48] . They have been demonstrated to induce apoptosis in cancer cells, making them promising candidates for cancer therapy [49] .…”