Synthesis and characterization of core-shell bimetallic nanoparticles for synergistic antimicrobial effect studies in combination with doxycycline on burn specific pathogens

Fakhri, Ali; Tahami, Shiva; Naji, Mahsa

doi:10.1016/j.jphotobiol.2017.02.014

Cited by 63 publications

(35 citation statements)

References 29 publications

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“…Other authors have designed a nanocomposite based on DOXY‐loaded polymeric nanoparticles in order to improve drug delivery and efficacy with considerable antimicrobial activity . In our case, the synthesis of DOXY‐AuNPs ( Scheme A) was carried out at room temperature by reduction of gold ions (AuCl 4 − ) using DOXY as reducing and capping agent on the growth process.…”

Section: Resultsmentioning

confidence: 99%

Novel Synthesis and Characterization of Doxycycline‐Loaded Gold Nanoparticles: The Golden Doxycycline for Antibacterial Applications

Haddada

Jeannot

Spadavecchia

2018

Part & Part Syst Charact

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Doxycycline (DOXY) is a tetracycline antibiotic with a potent antibacterial activity against a wide variety of bacteria. One potential strategy to enhance the penetration and the antibacterial activity of antibiotics is the use of nanotechnology. In this work, an innovative synthesis of stable PEGylated‐gold nanoparticles (PEG‐AuNPs) loaded with DOXY is reported. As far as it is known, this is the first report on the combination of DOXY with AuNPs as polymeric complex. The obtained nanoparticles are fully characterized by transmission electron microscopy, dynamic light scattering, zeta‐potential, and UV–vis and Raman spectroscopy. The stability and sustained activity of the drug in nanoparticles is determined on a panel of Gram‐positive and Gram‐negative bacteria in comparison with the native form of the drug. This combined therapeutic agent restores the susceptibility of DOXY and shows an antibacterial activity against major human pathogens.

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Section: Resultsmentioning

confidence: 99%

Novel Synthesis and Characterization of Doxycycline‐Loaded Gold Nanoparticles: The Golden Doxycycline for Antibacterial Applications

Haddada

Jeannot

Spadavecchia

2018

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“…Nanomaterials have extensive uses in areas such as textiles, medicinal, cosmetics, electronics, optics, energy generation and environmental sciences . Platinum (Pt), gold (Au) and silver (Ag) nanoparticles (NPs) have specific applications in the areas of biology and nanomedicine including diagnostic and therapeutic uses . Various conventional antibiotics are not good for longer use and drug overdosage may exacerbate problems associated with drug‐resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, there is a need for conjugated drug therapy and substitutive medicines to overcome such problems. Metal NPs have the potential to: (i) decrease drug dosages; (ii) increase the antibacterial effects of the drug; (iii) reduce drug adverse effects; and, (iv) target the drug at the proper site of action …”

Section: Introductionmentioning

confidence: 99%

“…The purity, reducibility and preferential reactivity of metal ions are the three important factors involved in the formation of bimetallic core‐shell NPs . Core‐shell NPs have found applications in various fields such as biology, material chemistry, sensors and catalysis . Pt‐based nanoalloys can be remarkably active catalysts regardless of the lower Pt content yet this contributes to their reduced cost …”

Section: Introductionmentioning

confidence: 99%

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One pot green synthesis of Pt, Co and Pt@Co core‐shell nanoparticles using Sechium edule

Chelli

Golder

2018

J of Chemical Tech & Biotech

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BACKGROUND: Common approaches for the synthesis of metallic nanostructured materials require the use of fine chemicals and energy-intensive processes. This work reports a simple eco-friendly (green) method to engineer the structure of cobalt (Co), platinum (Pt) and PtCo core-shell nanoparticles using plant-based analytes present in the extract of Sechium edule, the fruit of a perennial climber plant. RESULTS: Ascorbic acid (294 mg kg −1 dry fruit) was found to be the primary analyte and it acted for both metal ion reduction and nanoparticle destabilization forming a conjugate with the carboxylate group. The sharp rise in negative zeta-potential with the rise in pH from a highly acidic medium resulted from a strong destabilization tendency of Pt and Co nanostructures over a wide pH range. The size and colloidal stability, morphology and crystal structure were confirmed with the support of dynamic light scattering, transmission electron microscopy and X-ray diffraction. Co nanoprisms (47.3 nm), Pt nanospheres (28.6 nm) and PtCo core-shell (13.2-26.4 nm) nanoparticles were formed with a polydispersity index of 0.18-0.38. The synergistic effects such as ligand interaction between core and shell and the geometric effect improved the antibacterial activity against Bacillus subtilis and Escherichia coli bacteria in comparison to Pt nanospheres and Co nanoprisms, and these results were comparable with ciprofloxacin and cefprozil as the antibiotic controls. CONCLUSION: Plant analytes served as the electron donors for the formation of Pt and Co nanostructures and also stabilized the particles growth to tailor their structures for an improved antibacterial functionality.

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“…However, such methods are not effective, are expensive, need high energy input, and are not eco-friendly [17]. Recently, many approaches have been studied for the safe, cost-effective, and more effi cient treatment of heavy metal-loaded wastewater [18][19][20][21][22][23][24]. The physical adsorption method has emerged as the best alternative treatment method.…”

mentioning

confidence: 99%

Phytoremediation of Copper Pollution by Eight Aquatic Plants

DongFang¹,

Qitang²,

Deng³

et al. 2018

Pol. J. Environ. Stud.

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Synthesis and characterization of core-shell bimetallic nanoparticles for synergistic antimicrobial effect studies in combination with doxycycline on burn specific pathogens

Cited by 63 publications

References 29 publications

Novel Synthesis and Characterization of Doxycycline‐Loaded Gold Nanoparticles: The Golden Doxycycline for Antibacterial Applications

Novel Synthesis and Characterization of Doxycycline‐Loaded Gold Nanoparticles: The Golden Doxycycline for Antibacterial Applications

One pot green synthesis of Pt, Co and Pt@Co core‐shell nanoparticles using Sechium edule

Phytoremediation of Copper Pollution by Eight Aquatic Plants

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