Novel Synthesis and Characterization of Doxycycline‐Loaded Gold Nanoparticles: The Golden Doxycycline for Antibacterial Applications

Haddada, Maroua Ben; Jeannot, Katy; Spadavecchia, Jolanda

doi:10.1002/ppsc.201800395

Cited by 21 publications

(16 citation statements)

References 52 publications

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“… Ultrasound aided synthesis: This involves the ultrasound reduction of Au precursor in the presence of 2-propanol. The stabilizing agents used include citrate, disulphide and several dendrimers [ 68 , 69 , 70 ]; [ 71 ]. Laser ablation synthesis: Better results with accuracy and reproducibility have been obtained through laser ablation method, by virtue of size and shape.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of gold nanoparticles (AuNPs): A review

Sani

Cao

Cui

2021

Biochemistry and Biophysics Reports

239

157

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Gold nanoparticles are a kind of nanomaterials that have received great interest in field of biomedicine due to their electrical, mechanical, thermal, chemical and optical properties. With these great potentials came the consequence of their interaction with biological tissues and molecules which presents the possibility of toxicity. This paper aims to consolidate and bring forward the studies performed that evaluate the toxicological aspect of AuNPs which were categorized into in vivo and in vitro studies. Both indicate to some extent oxidative damage to tissues and cell lines used in vivo and in vitro respectively with the liver, spleen and kidney most affected. The outcome of these review showed small controversy but however, the primary toxicity and its extent is collectively determined by the characteristics, preparations and physicochemical properties of the NPs. Some studies have shown that AuNPs are not toxic, though many other studies contradict this statement. In order to have a holistic inference, more studies are required that will focus on characterization of NPs and changes of physical properties before and after treatment with biological media. So also, they should incorporate controlled experiment which includes supernatant control Since most studies dwell on citrate or CTAB-capped AuNPs, there is the need to evaluate the toxicity and pharmacokinetics of functionalized AuNPs with their surface composition which in turn affects their toxicity. Functionalizing the NPs surface with more peculiar ligands would however help regulate and detoxify the uptake of these NPs.

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Section: Introductionmentioning

confidence: 99%

Toxicity of gold nanoparticles (AuNPs): A review

Sani

Cao

Cui

2021

Biochemistry and Biophysics Reports

239

157

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“…Doxycycline is a broad-spectrum drug with its antimicrobial as well as antitumor activities [ 4 , 8 , 10 , 11 ]. PAR-1 is the receptor protein with which doxycycline binds to inhibit the tumor progression [ 6 ].…”

Section: Resultsmentioning

confidence: 99%

“…Doxycycline is a wide-spectrum drug belonging to the tetracycline family of antibiotics, which has been a drug of choice for treatment of several types of bacterial infections [ 4 ]. Protease-activated receptor-1 (PAR-1) is the member of PARs (protease-activated receptors) family that was identified in 1991 by two independent laboratories during the investigation of thrombin signaling pathway in both hamster and human cells.…”

Section: Introductionmentioning

confidence: 99%

Drug-Based Gold Nanoparticles Overgrowth for Enhanced SPR Biosensing of Doxycycline

2020

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In clinical chemistry, frequent monitoring of drug levels in patients has gained considerable importance because of the benefits of drug monitoring on human health, such as the avoidance of high risk of over dosage or increased therapeutic efficacy. In this work, we demonstrate that the drug doxycycline can act as an Au nanoparticle (doxy-AuNP) growth and capping agent to enhance the response of a surface plasmon resonance (SPR) biosensor for this drug. SPR analysis revealed the high sensitivity of doxy-AuNPs towards the detection of free doxycycline. More specifically, doxy-AuNPs bound with protease-activated receptor-1 (PAR-1) immobilized on the SPR sensing surface yield the response in SPR, which was enhanced following the addition of free doxy (analyte) to the solution of doxy-AuNPs. This biosensor allowed for doxycycline detection at concentrations as low as 7 pM. The study also examined the role of colloidal stability and growth of doxy-AuNPs in relation to the response-enhancement strategy based on doxy-AuNPs. Thus, the doxy-AuNPs-based SPR biosensor is an excellent platform for the detection of doxycycline and demonstrates a new biosensing scheme where the analyte can provide enhancement.

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“…In another study semisynthetic tetracycline like doxycycline was coated with AuNPs. The result showed that after conjugation susceptibility of the doxycycline was enhanced and has better antibacterial potential against many pathogens (Haddada et al 2018 ). The AuNPs were also used with antiprotozoal and antifungal drugs like fluconazoal, Amphotericin B and nystatin and it was observed that these drugs after conjugation with AuNPs were more bioactive against Acanthamoeba castellanii (Anwar et al 2019 ).…”

Section: Role Of Coated Nanoparticles In Overcoming the Antibacterial Resistancementioning

confidence: 99%

Outer Membrane Protein‐Coated Nanoparticles as Antibacterial Vaccine Candidates

Anwar

Muhammad

Akhtar

et al. 2021

Int J Pept Res Ther

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Nanoformulations are novel therapeutic strategies as compared to traditional treatments. The development of biomimetic nanoparticles by combining the natural cellular material with synthetic nanoparticles has inspired innovative vaccine strategies for modifying the antibacterial immunity. A lot of work has been done in which synthetic nanoparticles are coated with biomimetic cellular membranes for enhancement of biological functions and treatments. Outer membrane protein of bacteria not only act as adjuvant but also contain a large number of immunogenic antigens that play an important role in motivating the native immunity and stimulating the immune responses of the body. Outer membrane protein coating onto the surfaces of synthetic nanoparticles has synergistic effects to produce antibacterial responses. This article reviews the recent improvements related to the bacterial membrane-coated nanoparticles for antibacterial immunization.

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Novel Synthesis and Characterization of Doxycycline‐Loaded Gold Nanoparticles: The Golden Doxycycline for Antibacterial Applications

Cited by 21 publications

References 52 publications

Toxicity of gold nanoparticles (AuNPs): A review

Toxicity of gold nanoparticles (AuNPs): A review

Drug-Based Gold Nanoparticles Overgrowth for Enhanced SPR Biosensing of Doxycycline

Outer Membrane Protein‐Coated Nanoparticles as Antibacterial Vaccine Candidates

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