Synthesis and Characterization of Cu(II), Ni(II) and Co(II) Based 1, 4-Substituted Thosemicarbazone Complexes

Tada, Rakesh M.; Maheta, Tushar; Gondaliya, Mitesh B.; Shah, Manish K.

doi:10.7598/cst2013.349

Cited by 4 publications

(4 citation statements)

References 13 publications

(13 reference statements)

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“…calcd for C 12 2.3 | General procedure for the preparation of the metal complexes (1)(2)(3)(4)(5)(6)(7)(8)(9) All the new metal complexes 1-9 were prepared by the direct reaction between the ligand and the corresponding metal salts. : 142-144°C; yield (83%); FW: 249.332 g mol −1 .…”

Section: Synthesis Of 2hydroxybenzaldehyde-4-allyl-smethylisothiosementioning

confidence: 99%

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Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

Pahontu

Usataia

Graur

et al. 2018

Applied Organom Chemis

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2-Hydroxybenzaldehyde-4-allyl-S-methylisothiosemicarbazone and Cu (II), Co (III), Fe (III) and Cr (III) complexes were synthesized and characterized. The new obtained compounds were investigated by elemental analysis, magnetic susceptibility measurements, molar electric conductivity, IR, 1 H NMR, 13 C NMR, UV-Vis spectroscopy. In addition, the structure of the ligand and six complexes has been determined by single-crystal X-ray diffraction analysis.The Cu atom in complex 3 is penta-coordinated in a distorted square-pyramidal coordination geometry, while the metals in complexes 5-9 are in a distorted octahedral environment. For all compounds the antimicrobial activity was studied on a series of standard strains, such as Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Salmonella abony and Candida albicans.The in vitro antiproliferative activity of the ligand and complexes was screened on human leukemia HL-60 cells, human cervical epithelial HeLa cells, human epithelial pancreatic adenocarcinoma BxPC-3 cells, human muscle rhabdomyosarcoma spindle and large multinucleated RD cells. The primary screening on a wider series of cancer cells showed that copper coordination compound 2 manifests high activity towards HeLa, BxPC-3 and RD cancer cells, which is three-six times higher than the activity of doxorubicin. The selectivity index that is the ratio between the IC 50 value for the normal MDCK cells and IC 50 values for the cancer cells varies in the range 2.44-21.17. This index is 5.5-11 times higher for the copper coordination compound 2 than for the doxorubicin. Cr (III), Fe (III) and Co (III) coordination compounds 6-9 manifest high antioxidant activity towards ABTS •+ that exceeds 47-67 times the activity of Trolox. ---This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Section: Synthesis Of 2hydroxybenzaldehyde-4-allyl-smethylisothiosementioning

confidence: 99%

“…[1][2][3][4][5][6][7] In recent years, a number of thiosemicarbazone derivatives have been synthesized, and their biological activities were also evaluated. [1][2][3][4][5][6][7] In recent years, a number of thiosemicarbazone derivatives have been synthesized, and their biological activities were also evaluated.…”

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confidence: 99%

Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

Pahontu

Usataia

Graur

et al. 2018

Applied Organom Chemis

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“…Aspartic proteases are a class of enzymes that play a causative role in numerous diseases such as malaria (plasma epsins), Alzheimer's disease (β-secretase), fungal infections (secreted aspartic proteases), and hypertension (renin) [1]. Proteases represent the class of enzymes which occupy a pivotal position with respect to their physiological roles as well as their commercial applications.…”

Section: Introductionmentioning

confidence: 99%

“…Schiff's bases have been of good importance in coordination [1] and macrocyclic chemistry [2]. The synthesis of macrocyclic complexes have great potential applications in fundamental and applied sciences [3,4,5]; biochemistry, material science, catalysis, encapsulation, activation, transport and separation phenomena, hydrometallurgy, etc.…”

Section: Introductionmentioning

confidence: 99%

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Zayed¹,

Belal²,

Ragha³

2018

J Transition Met Complexes

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The complexing behavior of benzoylhydrazone Schiff's base (A1), with the IUPAC name (2(1-hydrazonoethyl)phenol), towards the transition metal ions, namely, Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Hg(II), Ce(IV), and UO 2 (II), has been examined by elemental analyses, magnetic measurements of some of them, electronic spectra, FT-IR, 1 H-NMR, and 13 C-NMR. Thermal properties and decomposition kinetics of all complexes are investigated. The interpretation of kinetic parameters of thermal decomposition stages of some of them has been evaluated using CoatsRedfern equation. The antifungal activities of the free ligand and its metal complexes have been tested in vitro against two types of fungi: Aspergillus fumigatus, RCMB 02568; Candida albicans, RCMB 05036. Besides, two gram-positive (Bacillus subtilis, RCMB 010067; Streptococcus pneumoniae, RCMB 010010) and two gram-negative (Escherichia coli, RCMB 010052; Pseudomonas aeruginosa, RCMB 010043) bacteria were used as test organisms in order to assess the complexes' antimicrobial potential. It is clear from this survey that the A1 complexes are of high biological activities as antifungal, in which Cu-A1 and Co-A1 are the most efficient complexes in a level more or less approaches that of the amphotericin standard. It also indicates that the Cu-A1 and Mn-A1 have the largest biological effects on gram-positive bacteria of both kinds, and that Cu-A1 complex has a more effect (32.4 ± 0.30) or of the same order of magnitude (23.8 ± 0.20) as that of the ampicillin standard (23.8 ± 0.2).

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Novel Fe(III), Co(III), Ni(II), Cu(II) coordination compounds involving 2-[(2-hydroxyphenyl)methylene]hydrazine-N-(2-propenyl)-carbothioamide as ligand: Synthesis, crystal structures and spectral characteristics

Orysyk

Repich

Bon

et al. 2014

Inorganica Chimica Acta

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Synthesis and Characterization of Cu(II), Ni(II) and Co(II) Based 1, 4-Substituted Thosemicarbazone Complexes

Cited by 4 publications

References 13 publications

Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Novel Fe(III), Co(III), Ni(II), Cu(II) coordination compounds involving 2-[(2-hydroxyphenyl)methylene]hydrazine-N-(2-propenyl)-carbothioamide as ligand: Synthesis, crystal structures and spectral characteristics

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