Synthesis and characterization of Cu(II), Co(II) and Ni(II) complexes of a benzohydrazone derivative: Spectroscopic, DFT, antipathogenic and DNA binding studies

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

“…[ 8 ] For this aim, a number of transition metals such as zinc, cobalt, copper, nickel, ruthenium, and iridium [ 9,10 ] and ligands such as hydrazones, Schiff bases, azo dyes, and phosphines are used . [ 11–14 ] These ligands, owing to coordination to a metallic center, have their electron density modified, especially by the delocalization of π‐electrons. These changes in electron density may alter the biological activity of ligands by affecting intermolecular interactions and lipophilicity.…”

DNA Interactions and Antiproliferative Activity Studies of Octahedral Nickel Complexes of Two Extended Phenanthrolines

“…The level of binding values of the compounds are within average compared to other nickel complexes in the literature, [29,30] the binding constants of the [Ni(phen) 2 (dppz)] 2 + and [Ru(phen) 2 (dppz)] 2 + complexes were 1.5 × 10 5 M À 1 and above 10 6 M À 1 , respectively. [113,114] The octahedral [Ru-(phen) 2 (ipbd)] 2 + (5.30 × 10 5 M À 1 ), [63] [Ru(bpy) 2 (fpp)] 2 + (1.73 × 10 5 M À 1 ), [7] [Ru(bpy) 2 (bdip)] 2 + (3.3 × 10 4 M À 1 ), [13] [Co-(phen) 2 (ciip)] 2 + (3.63 × 10 5 M À 1 ), [46] (Ru(phen) 2 (mcmip)] 2 + (4.97 × 10 4 M À 1 ), [21] [Co(phen) 2 (hnaip)] 2 +…”

“…Based on this, the work area of cancer drugs has been expanded by reducing the harmful effects of drugs and expanding the activity area. Metal complexes containing especially Ru(III) for which the highest DNA affinities have been measured, Pt(II), [26][27][28] Ni(II), [29][30][31][32][33][34][35][36] Cu(II), [29][30][31][37][38][39] Co(III), [40][41][42][43][44][45][46] Zn(II), [47,48] Au(III) [49,50] and Fe(III) [51] have also attracted attention as anticancer agents. [52][53][54] Metal complexes of DNA-intercalating polypyridyl ligands with an extended π-conjugation of imidazo [4,5-f] [1,10]phenanthroline derivatives at 2-position containing substituted benzene, naphthalene or larger rings and a number of heterocyclic ring systems (Figure 1) are still popular for DNA-targeted cancer therapy, DNA condensation for gene therapy and DNA sensing through fluorescence.…”

Analysis of Relationship Between Some Disazo Dyes Derived from 2,4-Dihydroxyquinoline and Its Anticancer and DNA Binding Properties by Density Functional Theory

“…Although there are studies in the literature using DFT on anticancer and DNA binding, the molecules have been theoretically examined in the studies, but no significant relationship has been established between the electronic and anticancer properties of the compounds [41][42][43][44][45][46][47][48][49][50]. In this study, a detailed atom in molecule (AIM), natural bond orbital (NBO), density of state (DOS), non-covalent interaction (NCI), Fukui function, electron localization function (ELF), and electron delocalization range (EDR) analysis of the compounds were done and the relationship between the electronic properties of these compounds and DNA binding capacity and the cytotoxicity against HeLa and PC3 cancer cell lines was investigated.…”