Synthesis and characterization of dioxomolybdenum complexes of semicarbazones

Kanoongo, Neeta; Singh, Ranvir; Tandon, J. P.

doi:10.1007/bf01225124

Cited by 18 publications

(5 citation statements)

References 4 publications

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“…The chemical shifts observed in 13C spectra (Table 3) of the complexes do not differ from those of FASC. These values are in good agreement with those given for similar compounds [2,26,27]. However, the relative intensities are modified : e.g.…”

Section: Nmr Spectrasupporting

confidence: 89%

Synthesis and characterization of metallic complexes of 3-(2-furyl) 2-propenal semicarbazone with d element dihalides

et al. 1997

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2-propenal semicarbazone (FASC) and CO ll, Ni n, CuII, Zn H and Cd I! chlorides or bromides gave the complexes: [M(FASC)eX2], [M(FASC)2]X2 or [M(FASC)X2] which were characterized starting from elemental analysis and molar conductances. Their structures are discussed on the basis of magnetic moments, infrared and electronic spectra ; in addition, the NMR data are used in the case of Zn H and Cd u species. The main cell parameters are given using X-ray diffraction powder diagrams.

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Section: Nmr Spectrasupporting

confidence: 89%

Synthesis and characterization of metallic complexes of 3-(2-furyl) 2-propenal semicarbazone with d element dihalides

et al. 1997

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“…bands are reported in Table 2. There is no indication of a band which could be assigned to the enol form of the compound [3,16].…”

Section: Ir Spectramentioning

confidence: 91%

“…A solution of FPSC (2.27 g, 0.01 mol) in EtOH (45 cm 3 ) was heated to reflux and a solution of CoBr 2 AE 6H 2 O (3.42 g, 0.0055 mol) in EtOH (35 cm 3 ) was added dropwise. The mixture was boiled under reflux for 6 h. After standing at room temperature, the solution was heated to reflux for 4 h and the EtOH was removed by * Author for correspondence distillation while n-BuOH (80 cm 3 ) was added.…”

Section: Dibromobis(2-furfural 4-phenyl Semicarbazone)cobalt(ii) (2)mentioning

confidence: 99%

“…We have previously reported the synthesis and characterization of complexes obtained from 3-(2-furyl) 2-propenal semicarbazone (FASC) [1], 2-furaldehyde semicarbazone (FSC) and 5-methyl-(2-furaldehyde) semicarbazone (MFSC) [2]. The co-ordinating properties of various semicarbazones have also been studied [3][4][5] as well as those of many thiosemicarbazones [6][7][8][9][10][11][12][13][14]. In this paper, we present the synthesis and characterization of new metal complexes of 2-furfural 4-phenyl semicarbazone FPSC (Figure 1) and cobalt(II), nickel(II), copper(II) and cadmium(II) chlorides and bromides.…”

Section: Introductionmentioning

confidence: 99%

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Ibrahim

Khan

Bouet

2002

Transition Metal Chemistry

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The synthesis of Co II , Ni II , Cu II and Cd II complexes of 2-furfural 4-phenyl semicarbazone (FPSC) with stoichiometric formulae: (FPSC)] and [(CdCl 2 ) 2 (FPSC)] has been obtained for the first time. The complexes were characterized by elemental analysis, molar conductivity, magnetic measurements, i.r., far i.r. and electronic spectra. FPSC is deduced to act as a bidentate ligand in the Co II , Ni II and Cu II complexes and as a tetradentate one in [(CdCl 2 ) 2 (FPSC)].

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“…General Compounds 1a, 22) 1b, 23) 1h, 24) 1f, 25) 4a, 26) 3b, 23) 3f, 3g, 3h 27) and 4h 28) are known compounds and synthesis and spectral data of them are available in the literature. MeltChart 2.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Novel Indole Hydrazone Derivatives and Evaluation of Their Antiplatelet Aggregation Activity

et al. 2013

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Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new indole hydrazone derivatives were evaluated for their ability to inhibit platelet aggregation induced by adenosine diphosphate (ADP) and arachidonic acid (AA). Compounds 1h and 3h exhibited remarkable activity against arachidonic acid induced platelet aggregation with IC 50 values comparable to that of indomethacin and compound 1i efficiently inhibited platelet aggregation induced by both ADP and AA.Key words antiplatelet aggregation; indole; hydrazone Thromboembolic disorders including cardiovascular and cerebrovascular events continue to be the major causes of death in the industrial countries and worldwide.1) In the pathogenesis of thromboembolic disorders, platelets play the major role. Activation of the platelets by a complex of biochemical pathways and multitude of mediators is the primary step in the progress of these diseases.2) Of the physiological agonists of platelet aggregation with medical importance include arachidonic acid (AA) that is metabolized by platelet cyclooxygenase-1 (COX-1) to different prostaglandins with inflammatory and platelet-aggregation properties; adenosine diphosphate (ADP) that acts on purinergic receptors on the platelet-known as P2Y receptors-and thrombin, a potent agonist that forms stable platelet aggregates. 2,3)By targeting the pathways in which the above mentioned mediators are involved, antiplatelet drugs have been developed to control the pathogenic activation of the platelets. Acetyl salicylic acid (a nonselective irreversible COX inhibitor) and clopidogrel (an irreversible antagonist of P2Y 12 ) are the most commonly prescribed oral antiplatelet drugs to date. However, use of these drugs is associated with a high risk of bleeding. 4)Also undesired complications of neutropenia and thrombotic thrombocytopenic purpura (TTP) pose limitation on the use of clopidogrel. 4,5) Besides, resistance to both drugs makes the antiplatelet therapy more complicated. 6) Hence, research for novel antiplatelet drugs with improved safety and efficacy profiles is necessary.Hydrazones are an important class of compounds which have been demonstrated to possess antimicrobial, analgesic, antiinflamatory, anticonvulsant, antitubercular, antitumoral and antiplatelet activities. 7) Many evidences suggest that the hydrazone moiety possess a pharmacophoric character for the inhibition of COX and thus antiplatelet aggregation activity. Fraga et al., have reported a novel group of heterocyclic acylhydrazone derivatives with antiplatelet aggragation activity on rabbit platelet-rich plasma. 8) They also reported a group of phenothiazine-1-acylhydrazone derivatives 9) as new prototype of antiplatelet derivatives which act in the arachidonic acid pathway probably by inhibition of platelet C...

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Synthesis and characterization of dioxomolybdenum complexes of semicarbazones

Cited by 18 publications

References 4 publications

Synthesis and characterization of metallic complexes of 3-(2-furyl) 2-propenal semicarbazone with d element dihalides

Synthesis and characterization of metallic complexes of 3-(2-furyl) 2-propenal semicarbazone with d element dihalides

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Synthesis of Novel Indole Hydrazone Derivatives and Evaluation of Their Antiplatelet Aggregation Activity

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