Synthesis and Characterization of Fullero-C60 α-Amino Acids with Antiviral Properties

Khalikov, Sh. Kh.; Sharipova, Dinara; Zafarov, S.Z.; Umarkhon, M.; Alieva, S. V.

doi:10.1007/s10600-017-1924-4

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…[ 25 ] Fullerene derivatives with amino acid‐based addends demonstrated pronounced anti‐influenza A/H5N1 activity. [ 26 ] Water‐soluble C 60 fullerene conjugates with γ‐cyclodextrin effectively inhibited influenza A/H1N1 virus in vitro at micromolar concentrations. [ 27 ] C 70 fullerene functionalized with eight residues of phenylbutanoic acid simultaneously suppressed the replication of three different strains of influenza virus.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity^†

et al. 2023

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Comprehensive Summary Herein, we present a facile synthesis of amide‐type water‐soluble fullerene derivatives decorated with five residues of amino acids. As compared to the previously developed approaches, the proposed method enables usage of a broad range of amino acids, including those unstable under Friedel‐Crafts reaction conditions. Furthermore, it is fully tolerant to the nature of the sixth addend X in C60R5X precursor compounds and allows one to obtain fullerene derivatives with X=Cl, H, alkyl. The synthesized amide‐type water‐soluble fullerene derivatives demonstrated promising antiviral activities against rimantadine‐resistant influenza А/Puerto Rico/8/34 (Н1N1) virus in vitro.

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Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity^†

et al. 2023

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“…They can be used as a targeted component of drug delivery systems. It is known from the literature data that some of the fullerene derivatives exhibited pronounced anticancer activity [ 3 , 4 , 5 , 6 ], antiviral (including anti-HIV) [ 7 , 8 , 9 , 10 , 11 ], and antibacterial [ 4 , 12 , 13 ] activity. It was also shown that fullerenes and fullerene-dye hybrid structures have a pronounced antitumor photodynamic effect [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Organization of Fullerene Derivatives in Solutions and Biological Cells Studied by Pulsed Field Gradient NMR

Avilova

Chernyak

Soldatova

et al. 2022

IJMS

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Fullerene derivatives are of great interest in various fields of science and technology. Fullerene derivatives are known to have pronounced anticancer and antiviral activity. They have antibacterial properties. Their properties are largely determined by association processes. Understanding the nature and properties of associates in solvents of various types will make it possible to make significant progress in understanding the mechanisms of aggregation of molecules of fullerene derivatives in solutions. Thus, this work, aimed at studying the size and stability of associates, is relevant and promising for further research. The NMR method in a pulsed field gradient was used, which makes it possible to directly study the translational mobility of molecules. The sizes of individual molecules and associates were calculated based on the Stokes–Einstein model. The lifetime of associates was also estimated. The interaction of water-soluble C60 fullerene derivatives with erythrocytes was also evaluated. The values of self-diffusion coefficients and the lifetime of molecules of their compounds in cell membranes are obtained. It is concluded that the molecules of fullerene derivatives are fixed on the cell surface, and their forward movement is controlled by lateral diffusion.

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Biocompatibility and biological activity of C70 fullerene adduct with L-threonine (C70(C4H9NO3)2)

Sharoyko

Serebryakov

Ageev

et al. 2022

Biochemical and Biophysical Research Communications

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Synthesis and Characterization of Fullero-C60 α-Amino Acids with Antiviral Properties

Cited by 9 publications

References 6 publications

Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity^†

Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity^†

Self-Organization of Fullerene Derivatives in Solutions and Biological Cells Studied by Pulsed Field Gradient NMR

Biocompatibility and biological activity of C70 fullerene adduct with L-threonine (C70(C4H9NO3)2)

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Synthesis and Characterization of Fullero-C60 α-Amino Acids with Antiviral Properties

Cited by 9 publications

References 6 publications

Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity†

Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity†

Self-Organization of Fullerene Derivatives in Solutions and Biological Cells Studied by Pulsed Field Gradient NMR

Biocompatibility and biological activity of C70 fullerene adduct with L-threonine (C70(C4H9NO3)2)

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Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity^†

Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity^†