Synthesis and characterization of highly-magnetic biodegradable poly(d,l-lactide-co-glycolide) nanospheres

Liu, Xianqiao; Kaminski, Michael; Chen, Haitao; Torno, Michael D.; Taylor, LaToyia; Rosengart, Axel J.

doi:10.1016/j.jconrel.2006.11.031

Cited by 88 publications

(65 citation statements)

References 26 publications

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“…373 There are indications that magnetic HAP and electrically polarized one (owing to OH groups in HAP crystal lattice) possess a more pronounced osteogenic response. 374,375 The structure and composition of HAP have been shown to be stable upon substitution with exogenous metallic ions in the lattice.…”

Section: Prospective Applicationsmentioning

confidence: 99%

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

2010

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The first part of this review looks at the fundamental properties of hydroxyapatite (HAP), the basic mineral constituent of mammalian hard tissues, including the physicochemical features that govern its formation by precipitation. A special emphasis is placed on the analysis of qualities of different methods of synthesis and of the phase transformations intrinsic to the formation of HAP following precipitation from aqueous solutions. This serves as an introduction to the second part and the main subject of this review, which relates to the discourse regarding the prospects of fabrication of ultrafine, nanosized particles based on calcium phosphate carriers with various therapeutic and/or diagnostic agents coated on and/or encapsulated within the particles. It is said that the particles could be either surface-functionalized with amphiphiles, peptides, proteins, or nucleic acids or injected with therapeutic agents, magnetic ions, or fluorescent molecules. Depending on the additive, they could be subsequently used for a variety of applications, including the controlled delivery and release of therapeutic agents (extracellularly or intracellularly), magnetic resonance imaging and hyperthermia therapy, cell separation, blood detoxification, peptide or oligonucleotide chromatography and ultrasensitive detection of biomolecules, and in vivo and in vitro gene transfection. Calcium phosphate nanoparticles as carriers of therapeutic agents that would enable a controlled drug release to treat a given bone infection and at the same be resorbed in the body so as to regenerate hard tissue lost to disease are emphasized hereby as one of the potentially attractive smart materials for the modern medicine.

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Section: Prospective Applicationsmentioning

confidence: 99%

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

2010

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“…Other research groups investigated highly magnetic nanoparticles with biodegradable polymer coating also for applications in biology and medicine. The nanocompounds synthesized presented good encapsulation capability as well as high magnetic response (magnetization values in the range of 26 -40 emu/g) due to a fact of possessing a lot of magnetic material (even up to 60 %) (Liu et al, 2007a). Water-dispersible nanospheres of iron oxide with coating of oleic acid and Pluronic were also investigated as drug delivery systems.…”

Section: Drug Deliverymentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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“…12 Most studies used iron oxides coated with oleic acid in order to make the surface hydrophobic and thus more compatible with PLGA. [13][14][15] Although oleic acid has been recognized as an unsaturated fatty acid with numerous benefits to human health, currently, some articles has been questioning possible risks that this fatty acid may lead to the human body. 16 The findings suggest that exposure of low concentrations of oleic acid negatively affects the barrier function of the intestinal epithelium, including mechanisms that prevent absorption of potentially toxic substances common in food.…”

Section: Introductionmentioning

confidence: 99%