Synthesis and characterization of hydroxyapatite and composite based on it with collagen/alginate

Serhiienko, Alla; Dontsova, Tetiana; Yanushevska, Olena; Lapinskyi, Andrii; Krymets, Grigory

doi:10.1007/s11696-021-01841-2

Cited by 9 publications

(1 citation statement)

References 33 publications

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“…The results seen in Figure 4 showed Subsequently, the crystallinity of the as-synthesized HAp was studied with X-ray diffraction (XRD). Figure 3d shows the presence of reflections peaks at certain 2θ angles, where they can be ascribed as follows: 22.59 [55][56][57][58]. The reflection peaks were also identified based on the Crystallography Open Database (COD)-in particular, the 96-901-1092 card.…”

Section: Turbiscan Analysismentioning

confidence: 99%

Nanohydroxyapatite Loaded with 5-Fluorouracil and Calendula officinalis L. Plant Extract Rich in Myo-Inositols for Treatment of Ovarian Cancer Cells

Osial,

Wilczewski,

Szulc

et al. 2023

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In this study, the hydroxyapatite (HAp) in the form of nanoparticles was synthesized through the wet co-precipitation method and loaded with plant extract from Calendula officinalis L. rich in biologically active myo-inositol, and the 5-fluorouracil anticancer drug. The obtained nanomaterials have rod-like structures approx. 30 nm in diameter and 100 nm in length. FT-IR analysis results proved the immobilization of biologically active compounds. The loading of plant extract into the carrier improved the stability of colloidal suspension, which was confirmed with turbidimetry. The composite modified with calendula extract and drug (HAp@Cal@5-flu) effectively scavenges the DPPH radicals, with a radical scavenging activity (RSA) of about 20.0 ± 1.3%. The effect is supported by the DFT calculations of the HOMO-LUMO, presenting the chemical reactivity of the molecules loaded into the HAp. The in vitro cytotoxicity results on SKOV-3 ovarian cancer cells show the pronounced cytotoxic effect of the HAp@Cal@5-flu. The calendula extract loading into the carrier provided better interactions with the tumorous biomimetic membranes studied with a Langmuir trough, making it a promising material in nano-biomedicine, including drug delivery and targeted cancer treatment.

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Section: Turbiscan Analysismentioning

confidence: 99%