Synthesis and characterization of iron-substituted hydroxyapatite via a simple ion-exchange procedure

Kramer, Erica; Morey, Aimee; Staruch, Margo; Suib, Steven L.; Jain, M.; Budnick, J. I.; Wei, Mei

doi:10.1007/s10853-012-6779-2

Cited by 56 publications

(41 citation statements)

References 19 publications

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“…These procedures all resulted in powders with pure apatite crystal structure. All powders in which magnetic properties were measured also showed a change from the diamagnetism of pure HA to para-or super para-magnetic properties of iron substituted HA [9,12,20,21].…”

Section: Introductionmentioning

confidence: 89%

“…Iron-substituted hydroxyapatite (FeHA) was produced using a simple ion exchange procedure [21]. HA powder, prepared as described above, was soaked in dilute ferric chloride solution (40% w/v, Fisher), at a concentration of 5 g/L, under moderate stirring for one hour, and then collected by filtration and washed thoroughly with deionized water.…”

Section: Hydroxyapatite and Iron-substituted Hydroxyapatite Synthesismentioning

confidence: 99%

“…Starting powder characterization: FeHA powder synthesized using the procedure described above was thoroughly characterized and reported in our previous work [21]. The SPEX milled pure HA and FeHA powders were also examined via a JEOL JSM 6335F Field Emission Scanning Electron Microscope (FESEM) prior to pressing into pellets.…”

Section: Sample Characterizationmentioning

confidence: 99%

“…This material was thoroughly characterized using methods including XRD, energy dispersive X-ray spectroscopy (EDX), inductively couple plasma atomic emission spectroscopy (ICP-AES), Fourier Transform Infrared Spectroscopy (FT-IR), and Vibrating Sample Magnetometer (VSM) and Superconductive Quantum Interference Device (SQUID) analysis [21]. These previous results showed that after iron substitution the powder retained characteristic apatite crystal structure and functional groups, but the iron doped samples displayed paramagnetic properties, as opposed to the diamagnetism of pure HA.…”

Section: Starting Powder Characterizationmentioning

confidence: 99%

“…Iron has been incorporated into the HA lattice during apatite synthesis, via controlled temperature and pH ion-exchange procedures, and via a simple room temperature ion exchange procedure with soaking time as short as 1 hour [7,[9][10][11][12]20,21]. These procedures all resulted in powders with pure apatite crystal structure.…”

Section: Introductionmentioning

confidence: 99%

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A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite

Kramer¹,

Zilm²,

Wei³

2013

Bioceram Dev Appl

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Hydroxyapatite (HA) is a widely studied biomaterial for bone grafting and tissue engineering applications. The crystal structure of HA lends itself to a wide variety of substitutions, which allows for tailoring of material properties. Iron is of interest in ion substitution in HA due to its magnetic properties. The synthesis and characterization of iron-substituted hydroxyapatite (FeHA) have been widely studied, but there is a lack of studies on the sintering behaviors of FeHA materials compared to pure HA. Studying the sintering behavior of a substituted apatite provides information regarding how the substitution affects material characteristics such as stability and bulk mechanical properties, thereby providing insight into which applications are appropriate for the substituted material. In this study both pure HA and FeHA were synthesized, pressed into pellets, and then sintered at temperatures ranging from 900-1300°C and 600-1100°C, respectively. The study thoroughly examined the comparative sintering behaviors of the two materials using density measurements, mechanical testing, X-ray diffraction, and electron microscopy. It was found that FeHA is considerably less thermally stable than pure HA, with decomposition beginning around 1200°C for pure HA samples, while at 700°C for the FeHA. The FeHA also had a much lower mechanical strength than that of the pure HA. An in vitro cell culture study was conducted by immersing FeHA powder in cell culture media, with HA powder at equivalent doses as a control, verified that FeHA is a biocompatible material. Although the FeHA would be unsuitable for bulk applications, it is a potential material for a variety of biomedical applications including drug delivery, cancer hyperthermia, and bone tissue engineering composites.

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Section: Introductionmentioning

confidence: 89%

Section: Hydroxyapatite and Iron-substituted Hydroxyapatite Synthesismentioning

confidence: 99%

Section: Sample Characterizationmentioning

confidence: 99%

Section: Starting Powder Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite

Kramer¹,

Zilm²,

Wei³

2013

Bioceram Dev Appl

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Formation of Amorphous Iron‐Calcium Phosphate with High Stability

Chen

Liu

et al. 2023

Advanced Materials

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Amorphous iron‐calcium phosphate (Fe‐ACP) plays a vital role in the mechanical properties of teeth of some rodents, which are very hard, but its formation process and synthetic route remain unknown. Here, the synthesis and characterization of an iron‐bearing amorphous calcium phosphate in the presence of ammonium iron citrate (AIC) are reported. The iron is distributed homogeneously on the nanometer scale in the resulting particles. The prepared Fe‐ACP particles can be highly stable in aqueous media, including water, simulated body fluid, and acetate buffer solution (pH 4). In vitro study demonstrates that these particles have good biocompatibility and osteogenic properties. Subsequently, Spark Plasma Sintering (SPS) is utilized to consolidate the initial Fe‐ACP powders. The results show that the hardness of the ceramics increases with the increase of iron content, but an excess of iron leads to a rapid decline in hardness. Calcium iron phosphate ceramics with a hardness of 4 GPa can be achieved, which is higher than that of human enamel. Furthermore, the ceramics composed of iron‐calcium phosphates show enhanced acid resistance. This study provides a novel route to prepare Fe‐ACP, and presents the potential role of Fe‐ACP in biomineralization and as starting material to fabricate acid‐resistant high‐performance bioceramics.

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Biomimetic Fe‐hydroxyapatite nanoparticle‐reinforced bisphenol A‐glycol methacrylate/triethyleneglycol‐dimethacrylate resins for dental restorative application

Ning

Zheng

Yang

et al. 2021

J of Applied Polymer Sci

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Commercial bisphenol A‐glycol methacrylate (BisGMA)/triethyleneglycol‐dimethacrylate (TEGDMA) have been widely used as dental restorative material; however, the poor mechanical and anti‐wear properties greatly limited their applied range. In this study, iron‐containing hydroxyapatite (FeHA) nanoparticles that mimic the chemical composition and microstructure of natural bamboo rat incisor enamel were synthesized and used as reinforcement in BisGMA/TEGDMA resins. The as‐prepared polycrystalline FeHA have a rod like morphology with uniformly dispersed iron. The effects of nanoparticle–resin weight ratios on the mechanical properties, tribological properties, and bioactivity of FeHA‐BisGMA/TEGDMA resins were investigated. In vitro bioactivity of the studied resin composites in artificial saliva showed that a dense and continuous apatite layer was formed on the surface of the resin composite. Findings revealed that doping a suitable content of FeHA nanoparticle, especially at 0.75 wt% FeHA, would significantly improve the tribological and mechanical properties as well as bioactivity of the dental resin composites.

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Synthesis and characterization of iron-substituted hydroxyapatite via a simple ion-exchange procedure

Cited by 56 publications

References 19 publications

A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite

A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite

Formation of Amorphous Iron‐Calcium Phosphate with High Stability

Biomimetic Fe‐hydroxyapatite nanoparticle‐reinforced bisphenol A‐glycol methacrylate/triethyleneglycol‐dimethacrylate resins for dental restorative application

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