Synthesis and Characterization of Isoquinolinyl Quinazolines and a Study of Their Antiviral and Antifungal Activities.

Pandey, V. K.; Pathak, Lalit; Mishra, Sheo K.

doi:10.1002/chin.200602169

Cited by 2 publications

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“…However due to some adverse effects of dopamine, it was thought to prepare the different heterocyclic molecules which possess lesser side effects. Quinazolinone is one of the most frequently encountered heterocycle in medicinal chemistry and its derivatives are known to possess numerous interesting biological properties which include antiparkinsonian as well, and different research groups are working in the direction to explore antiparkinsonian activity of this category [136][137].…”

Section: Anti Parkinsonian Activitymentioning

confidence: 99%

Quinazolinone Analogs as Potential Therapeutic Agents

Sharma¹,

Kaur²,

Pahwa

et al. 2011

CMC

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Quinazolinone scaffold has been considered as a magic moiety possessing myriad spectrum of medicinal activities. Diversity of biological response profile has attracted considerable interest of several researchers across the globe to explore this skeleton for its assorted therapeutic significance. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, antiinflammatory, antihistaminic, anticancer and so on. Moreover, the nucleus constitutes an integral structural component in a number of drugs currently employed in several clinical therapies. The present paper is an earnest attempt to provide an insight view on the current medicinal aspects of quinazolinone heterocycles alongwith brief discussion of their chemistry.

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Section: Anti Parkinsonian Activitymentioning

confidence: 99%

Quinazolinone Analogs as Potential Therapeutic Agents

Sharma¹,

Kaur²,

Pahwa

et al. 2011

CMC

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“…Nitrogen‐rich heterocycles, particularly quinazolines are extremely considerable skeletons in the field of pharmaceutical chemistry which offers a disparity of biological actions such as anti‐inflammatory, [23] antiviral, [24] antihistaminic, [25] anticonvulsant, [26] diuretic, and antihypertensive activities [27] . Additionally, nolatrexed as anti solid tumor and albaconazole as an antifungal and antihistaminic drugs with quinazolines core are available in the market.…”

Section: Introductionmentioning

confidence: 99%

Rational Design, Synthesis, in Vitro, and in Silico Studies of Chlorophenylquinazolin‐4(3H)‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors

Hajimiri

Khosravikia

Khoshneviszadeh

et al. 2022

Chemistry & Biodiversity

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Tyrosinase plays a pivotal role in the hyperpigmentation and enzymatic browning of fruit and vegetable. Therefore, tyrosinase inhibitors can be of interest in industries as depigmentation compounds as well as anti‐browning agents. In the present study, a series of chlorophenylquinazolin‐4(3H)‐one derivative were rationally designed and synthesized. The formation of target compounds was confirmed by spectral characterization techniques such as IR, 1H‐NMR, 13C‐NMR, and elemental analysis. Among the synthesized derivatives, compound 8l was proved to be the most potent inhibitor with an IC50 value of 25.48±1.19 μM. Furthermore, the results of the molecular docking study showed that this compound fitted well in the active site of tyrosinase with the binding score of −10.72.

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Synthesis and Characterization of Isoquinolinyl Quinazolines and a Study of Their Antiviral and Antifungal Activities.

Cited by 2 publications

References 0 publications

Quinazolinone Analogs as Potential Therapeutic Agents

Quinazolinone Analogs as Potential Therapeutic Agents

Rational Design, Synthesis, in Vitro, and in Silico Studies of Chlorophenylquinazolin‐4(3H)‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors

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