Synthesis and characterization of maleated cyclodextrin-grafted-silylated montmorillonite for the controlled release and colon specific delivery of tetracycline hydrochloride

Abstract

In order to exploit the potential of host-guest interaction of cyclodextrin molecules and the controlled release properties of sodium montmorillonite, we have developed a novel composite hydrogel (CH), namely maleated cyclodextrin-grafted-silylated montmorillonite (MACD-g-MPTMS/MMT) for colon specific tetracycline hydrochloride (TCH) drug delivery. The CH was characterized by using techniques such as FTIR, SEM and XRD. The effect of the pH on the encapsulation of TCH was studied and found to be maximum at pH 3.0. The study of the surface morphology of CH using SEM showed an irregular and rough surface morphology, which favors TCH drug loading. In TCH loaded CH, the shift of the FTIR bands of amide I and II in comparison to crystalline TCH suggested a strong interaction between the amide groups and the clay surfaces. The swelling behavior of CH was measured in different media and found to be a maximum at pH 7.4. The drug delivery results demonstrated that CH could successfully deliver TCH to the colon without losing the drug in the stomach, and could be a good candidate for an orally administered drug delivery system. Results showed that the prepared CH showed good biocompatibility in the range 10-75 mg ml 21 , being also able to effectively stimulate cell proliferation.

Optimization of tetracycline hydrochloride adsorption on amino modified SBA-15 using response surface methodology

“…There have been a few reports in sustain release of tetracycline [26][27][28][29][30][31]. Also, mesoporous silica has been used to immobilize antibiotics such as amoxicillin [20].…”

Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole

“…s was calculated using Eq. (1), which states that the lower the value of s is, the higher the swelling rate (Anirudhan et al 2012;Omidian et al 1998). …”

“…The Voigt model (Eq. 1) was employed to observe the rate of swelling of g-HPMC (M) (Anirudhan et al 2012;Omidian et al 1998).…”

“…It is therefore possible to develop pHsensitive hydrogels by incorporating amino, amide and carboxylic acid groups through proper selection of the grafted polymer. In particular, for colon-targeted drug release, pH-responsive graft copolymers derived from various modified biopolymers have gained much attention mainly because of the pH changes in the GI tract (Anirudhan et al 2012).…”

Poly(epsilon caprolactone)/clay nanocomposites via host–guest chemistry

“…To the best of our knowledge, no report is currently available in the literature regarding the preparation of polymer/clay nanocomposites using host-guest type complex system. In this study, firstly the cyclodextrin as host has been introduced to the hydroxyl groups of commercial montmorillonite clay (MMT-(CH 2 CH 2 OH) 2 ) by reacting a cyclic anhydride through esterification [54]. Poly(e-caprolactone) (PCL), a wellknown biodegradable polymer, is employed as guest polymer, which is able to form inclusion complexes with cyclodextrin.…”