Synthesis and characterization of microporous hollow core-shell silica nanoparticles (HCSNs) of tunable thickness for controlled release of doxorubicin

Deepika, D.; PonnanEttiyappan, JagadeeshBabu

doi:10.1007/s11051-018-4287-2

Cited by 15 publications

(5 citation statements)

References 41 publications

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“…A rapid drug release was observed for the FS1 sample in 25-100 min FS2 experienced a rapid release in 50-150 min, whereas for the FS3 and FS4 samples, the release occurred in 50-75 min and 25-75 min, respectively. Furthermore, Deepika et al reported that an optimum release speed of 43.9% was achieved after the 15 th min, with a silica layer thickness of 15 nm [67]. A high initial dose followed by a stable drug dose is generally beneficial for the administration of therapeutic drugs in the long run.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of magnetite/silica nanocomposites from natural sand to create a drug delivery vehicle

Taufiq

Nikmah

Hidayat

et al. 2020

Heliyon

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In this study, we report the synthesis of the magnetite/silica nanocomposites and their structural and functional groups, magnetic properties, morphology, antimicrobial activity, and drug delivery performance. The X-ray diffraction characterization showed that magnetite formed a spinel phase and that silica formed an amorphous phase. The particle sizes of magnetite increased from 8.2 to 13.2 nm with increasing silica content, and the particles were observed to be superparamagnetic. The nanocomposites tended to agglomerate based on the scanning electron microscopy images. The antimicrobial activity of the magnetite/silica nanocomposites revealed that the increasing silica content increased the inhibition zones by 74%, 77%, and 143% in case of Gram-positive bacteria (B. subtilis), Gram-negative bacteria (E. coli), and fungus (C. albicans), respectively. Furthermore, doxorubicin was used as the model compound in the drug loading and release study, and drug loading was directly proportional to the silica content. Thus, the increasing silica content increased the drug loading owing to the increasing number of OHÀ bonds in silica, resulting in strong bonds with doxorubicin. Based on this study, the magnetite/silica nanocomposites could be applied as drug delivery vehicles.

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Section: Resultsmentioning

confidence: 99%

Synthesis of magnetite/silica nanocomposites from natural sand to create a drug delivery vehicle

Taufiq

Nikmah

Hidayat

et al. 2020

Heliyon

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“…In step 1, The styrene (monomer) was polymerized by emulsion polymerization in water using 0.03g KPS as an initiator and 0.3g PVP as a stabilizer, following the well-established polystyrene synthesis technique [28]. In step 2, 36ml solution of styrene was prepared with water, with the ratio maintained at 1 : 9.…”

Section: Methodology 211 Preparation Of Polystyrene Templatementioning

confidence: 99%

“…As described in [28], the synthesis of caged silica follows a specific method. The PS has a negatively charged surface due to the sulphate group from the initiator (KPS).…”

Section: Mechanism Of Formation Of Caged Silicamentioning

confidence: 99%

Optimized caged silica synthesis with lithium chloride and calcium chloride impregnation for prospective desalination application

Khushnood,

Khan,

et al. 2023

J Porous Mater

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Caged Silica is an inorganic sorbent that is widely employed in a variety of applications, including catalysts, thermal insulation, energy storage batteries, and as an adsorbent in the extraction of fresh water. Researchers have devised several techniques to prepare mono-dispersed caged silica with standard morphology. Template synthesis is quite prominent due to its structural stability and versatility. In this work, we present synthesis of caged silica microsphere via hard template synthesis by employing the process of calcination at 550 • C for 4 hours at the rate of 3 • C/min and subsequent drying. Emulsion polymerization was utilized to develop the polystyrene required in the procedure. This study also looks at how different parameters like silica precursor concentration, surfactant concentration, and catalyst concentration affect silica morphology. It was investigated that caged silica synthesis was optimized at 1.5ml of TEOS, 1.25g of CTAB, 0.1g of PS and 75µl of NH 3 which was confirmed by SEM and TEM analysis. Surface area of caged silica was measured as 448m 2 /g with the stirring rate of 5 minutes. We also impregnated caged silica with 9% of hygroscopic salts (CaCl 2 and LiCl) and it showed substantial uptake improvement. Preliminary results showed that LiCl impregnated caged silica is more efficient at water uptake compared to CaCl 2 . The proposed composite adsorbent (Si-9-Li & Si-9-Ca) could be used for the desalination application.

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“…7 There are approaches that have been used to control the particle size of HMSN such as varying the concentration of synthesis components (silica precursors and catalysts), changing reaction conditions (temperature, pH), and addition of dispersing agents or capping agents. [8][9][10][11] Among these, capping agents seems to be a simple and effective method where molecules are added into the synthesis mixture to absorb selectively onto particles' surface, decrease the particle surface energy and consequently promote the growth of the particles. 12 Polyethylene glycol (PEG), a familiar water-soluble polyether with good biocompatibility, hydrophilicity and rapid degradability, has been commonly used as a capping agent in colloidal syntheses to control the size of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that nanoparticle size had important effects on not only their ability to overcome the transport barriers in biological tissues but also their drug loading capacity 7 . There are approaches that have been used to control the particle size of HMSN such as varying the concentration of synthesis components (silica precursors and catalysts), changing reaction conditions (temperature, pH), and addition of dispersing agents or capping agents 8–11 . Among these, capping agents seems to be a simple and effective method where molecules are added into the synthesis mixture to absorb selectively onto particles' surface, decrease the particle surface energy and consequently promote the growth of the particles 12…”

Section: Introductionmentioning

confidence: 99%

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

Nguyen

Tran

Truong‐Thi

et al. 2022

J of Applied Polymer Sci

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This study reports for the first time the usage of polyethylene glycol (PEG) as the capping agent to control mesoporous shell thickness of hollow mesoporous silica nanoparticles (HMSN)—a promising nanocarrier. HMSN was synthesized with hard template method and PEG with different molecular weights and concentrations would be added at the mesoporous coating. The samples dSiO2@MSN synthesized with and without PEG were analyzed DLS, field‐emission scanning electron microscopy, Brunauer–Emmett–Teller and Barrett–Joyner–Halenda to characterize their mesoporous shells. Meanwhile transmission electron microscope, Zeta potential, energy dispersive X‐ray spectroscopy, Fourier‐transform infrared, loading capacity, release profile and cytotoxicity analysis was conducted to characterize HSMNs. As PEG's molecular weight or concentration increased, the mesoporous shell thickness gradually raised. Particles synthesized in the presence of 2% PEG 6000 retained the monodispersed spherical morphology with a particle diameter of 95.40 nm and a mesoporous shell thickness of 14.40 nm, which was about 7.0 nm thicker. dSiO2@MSN‐P owned equal mesopore diameter and higher surface area compared to dSiO2@MSN‐0. HMSN‐P showed similar loading capacity but better sustained release profile than HMSN‐0. Moreover, both HMSN‐0 and HMSN‐P performed as biocompatible materials. This study would contribute a simple and effective method to control the shell thickness of HMSN with PEG for drug delivery applications.

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Synthesis and characterization of microporous hollow core-shell silica nanoparticles (HCSNs) of tunable thickness for controlled release of doxorubicin

Cited by 15 publications

References 41 publications

Synthesis of magnetite/silica nanocomposites from natural sand to create a drug delivery vehicle

Synthesis of magnetite/silica nanocomposites from natural sand to create a drug delivery vehicle

Optimized caged silica synthesis with lithium chloride and calcium chloride impregnation for prospective desalination application

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

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