Synthesis of magnetite/silica nanocomposites from natural sand to create a drug delivery vehicle

Abstract

In this study, we report the synthesis of the magnetite/silica nanocomposites and their structural and functional groups, magnetic properties, morphology, antimicrobial activity, and drug delivery performance. The X-ray diffraction characterization showed that magnetite formed a spinel phase and that silica formed an amorphous phase. The particle sizes of magnetite increased from 8.2 to 13.2 nm with increasing silica content, and the particles were observed to be superparamagnetic. The nanocomposites tended to agglomerate based on the scanning electron microscopy images. The antimicrobial activity of the magnetite/silica nanocomposites revealed that the increasing silica content increased the inhibition zones by 74%, 77%, and 143% in case of Gram-positive bacteria (B. subtilis), Gram-negative bacteria (E. coli), and fungus (C. albicans), respectively. Furthermore, doxorubicin was used as the model compound in the drug loading and release study, and drug loading was directly proportional to the silica content. Thus, the increasing silica content increased the drug loading owing to the increasing number of OHÀ bonds in silica, resulting in strong bonds with doxorubicin. Based on this study, the magnetite/silica nanocomposites could be applied as drug delivery vehicles.

Superparamagnetic Behaviour and Surface Analysis of Fe3O4/PPY/CNT Nanocomposites

“…The magnetic properties of Fe 3 O 4 /PPY/CNT nanocomposite were studied using vibrating-sample magnetometer. where the magnetization of magnetite decreased from 30 to 9 emu/gr after the incorporation of silica [17]. Furthermore, due to the small coercivity value, Fe 3 O 4 /PPY/CNTs can be classified as a soft magnet material group.…”

Fabrication of Mn1Zn Fe2O4 ferrofluids from natural sand for magnetic sensors and radar absorbing materials

“…The other materials were TMAH used as the surfactant, H 2 O used as the carrier liquid, HCl (38%) used as the solvent, and NH 4 OH (25%) used as the precipitating agent. Dried natural iron sand was separated from impurities using a permanent magnet to produce Fe 3 O 4 powder with a purity of 99.5% [ 15 ]. Twenty grams of Fe 3 O 4 powder was reacted with 58 mL of HCl using a magnetic stirrer for 30 min at room temperature to obtain ferric chloride and ferrous chloride.…”

“…Therefore, in this study, we developed a fabrication method of Mn 1 -x Zn x Fe 2 O 4 ferrofluids using abundant natural iron sand as the main precursor that is effective, efficient, inexpensive, and ecofriendly. Natural iron sand can be employed effectively to minimize the fabrication cost for the synthesis of high quality magnetic nanoparticles [ 15 ]. Moreover, to further reduce the fabrication cost, water was used as the polar carrier liquid in the fabrication of Mn 1 -x Zn x Fe 2 O 4 ferrofluids with a chain-like structure.…”

Separation Process of Tobacco Dust from Sand Impurities by Fluidized Fixed Bed

“…The subtraction of wavenumber was also referred as the decrement of sand impurities concentration. Furthermore, the specific peak of the magnetite/silica bond as Fe-O-Si was detected at 565 cm -1 only on the sample A [14][15][16]. Significantly, the disappearance of Fe-O-Si on FTIR spectra of sample B indicated that there was no interaction between magnetite and silica.…”