Synthesis and characterization of montmorillonite/N-(carboxyacyl) chitosan coated magnetic particle nanocomposites for controlled delivery of paracetamol

Anirudhan, T.S.; Gopal, S.; Sandeep, S.

doi:10.1016/j.clay.2013.11.039

Cited by 30 publications

(15 citation statements)

References 27 publications

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“…In simulated gastric fluid, MMT2 shows an ordered release of 61.44 % of the drug within 12. The slow ordered release is also observed in simulated intestinal fluid, which 39.41 % of drug released within 12 h. The drug release in simulated gastric fluid is much lower than that in simulated intestinal fluid, indicates that drug release properties of MMT2 are affected by pH [22]. Rapid initial burst release is not observed in this study as the other researchers observed [23][24][25], since the strong hydrophilic interaction between metformin HCl and montmorillonite occurred.…”

Section: Resultscontrasting

confidence: 45%

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

Putra¹,

Sitanggang²,

Suarya³

et al. 2017

Asian J. Chem.

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In this work, metformin HCl was encapsulated on citric acid activated montmorillonite as drug delivery system. The as-synthetized drug delivery systems were characterized by using FTIR and X-ray diffraction. FTIR spectra showed the presence of bending vibration of N-H from primary amines group and streching vibration of C=N at 1635.64 and 1506.41 cm -1 , respectively. X-ray diffraction pattern also showed a widening of the diffraction peaks of montmorillonite after encapsulated by metformin HCl. In vitro drug release results showed that the release of metformin HCl from the drug delivery system in simulated intestinal fluid (pH 7.4) higher than that in simulatied gastric fluid (pH 1.2) with a value of drug release of 61.44 % and 39.41 %. Metformin HCl release kinetics at each pH follow the zero-order model (pH 1.2 with R = 0.9924; pH 7.4 with R = 0.9972) suggested diffusion-controlled release mechanism.

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Section: Resultscontrasting

confidence: 45%

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

Putra¹,

Sitanggang²,

Suarya³

et al. 2017

Asian J. Chem.

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“…165 The addition of clay minerals to the polymeric hydrogels and interactions with the polymers can improve the mechanical properties and absorptivity of nanocomposite hydrogels. 166 Clay mineral-containing nanocomposite hydrogels with suitable strength and elasticity can be expected to be an effective wound dressing material. Moreover, due to the enhancement of adsorption caused by the CNPs, the nanocomposite hydrogels can more efficiently absorb the wound exudates and keep the wound clean.…”

Section: Wound Dressingmentioning

confidence: 99%

Recent advances in clay mineral-containing nanocomposite hydrogels

et al. 2015

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Clay mineral-containing nanocomposite hydrogels have been proven to have exceptional composition, properties, and applications, and consequently have attracted a significant amount of research effort over the past few years. The objective of this paper is to summarize and evaluate scientific advances in clay mineral-containing nanocomposite hydrogels in terms of their specific preparation, formation mechanisms, properties, and applications, and to identify the prevailing challenges and future directions in the field. The state-of-the-art of existing technologies and insights into the exfoliation of layered clay minerals, in particular montmorillonite and LAPONITE s , are discussed first. The formation and structural characteristics of polymer/clay nanocomposite hydrogels made from in situ free radical polymerization, supramolecular assembly, and freezing-thawing cycles are then examined. Studies indicate that additional hydrogen bonding, electrostatic interactions, coordination bonds, hydrophobic interaction, and even covalent bonds could occur between the clay mineral nanoplatelets and polymer chains, thereby leading to the formation of unique three-dimensional networks. Accordingly, the hydrogels exhibit exceptional optical and mechanical properties, swelling-deswelling behavior, and stimuli-responsiveness, reflecting the remarkable effects of clay minerals. With the pivotal roles of clay minerals in clay mineral-containing nanocomposite hydrogels, the nanocomposite hydrogels possess great potential as superabsorbents, drug vehicles, tissue scaffolds, wound dressing, and biosensors. Future studies should lay emphasis on the formation mechanisms with in-depth insights into interfacial interactions, the tactical functionalization of clay minerals and polymers for desired properties, and expanding of their applications.

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“…Reddy and Sailaja supported that the aspirin‐loading capacity of ethyl cellulose nanoparticles was 0.35 mg mg −1 . Meanwhile, Anirudhan et al, showed that the loading capacity of monthmorillonite/N(carboxyacyl) chitosan‐coated magnetite nanoparticles for paracetamol was 9.60 × 10 −4 mg mg −1 . It is noteworthy that starch‐citrate nanoparticles displayed a much higher loading capacity of 5.00 mg mg −1 for paracetamol.…”

Section: Resultsmentioning

confidence: 99%

“…Besides, intermolecular interactions between drug molecules and carriers also influenced the drug‐loading capacity of the latter . The electrostatic interactions between COO − groups of starch‐citrate nanoparticles and −OH 2 + (leaving group of paracetamol due to protonation of OH of paracetamol occurred when in contact with starch‐citrate solution) during nanoprecipitation explained the high paracetamol‐loading capacity of starch‐citrate nanoparticles …”

Section: Resultsmentioning

confidence: 99%

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

et al. 2019

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Starch‐citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch‐citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop‐wise addition of dissolved starch‐citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH‐responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero‐order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch‐citrate nanoparticles are non‐toxic and hence are suitable for biomedical applications as pH‐responsive drug carriers.

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Synthesis and characterization of montmorillonite/N-(carboxyacyl) chitosan coated magnetic particle nanocomposites for controlled delivery of paracetamol

Cited by 30 publications

References 27 publications

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

Recent advances in clay mineral-containing nanocomposite hydrogels

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

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