Synthesis and characterization of new types of halogenated and alkylated imidazolidineiminothiones and a comparative study of their antitumor, antibacterial, and antifungal activities

Moussa, Ziad; El‐Sharief, Marwa A. M. Sh.; El‐Sharief, A. M. Sh.

doi:10.1016/j.ejmech.2011.03.009

Cited by 38 publications

(9 citation statements)

References 57 publications

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“…Due to their properties, chloro-organic compounds are used in many areas. They are very often applied as antifungal [1,2], antibacterial [3], antifidant [4,5], cytotoxic, and anticancer agents [6]. They are also used as organic solvents, refrigerants and media, dielectrics, pesticides, monomers for the production of plastic materials, and intermediates for organic synthesis [7].…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of Bicyclic Halolactones with a Methyl Group in the Cyclohexane Ring into Hydroxylactones and Their Biological Activity

et al. 2016

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Abstract:The aim of this study was the chemical synthesis of a series of halo-and unsaturated lactones, as well as their microbial transformation products. Finally some of their biological activities were assessed. Three bicyclic halolactones with a methyl group in the cyclohexane ring were obtained from the corresponding γ,δ-unsaturated ester during a two-step synthesis. These lactones were subjected to screening biotransformation using twenty two fungal strains. These strains were tested on their ability to transform halolactones into new hydroxylactones. Among the six strains able to catalyze hydrolytic dehalogenation, only two (Fusarium equiseti, AM22 and Yarrowia lipolytica, AM71) gave a product in a high yield. Moreover, one strain (Penicillium wermiculatum, AM30) introduced the hydroxy group on the cyclohexane ring without removing the halogen atom. The biological activity of five of the obtained lactones was tested. Some of these compounds exhibited growth inhibition against bacteria, yeasts and fungi and deterrent activity against peach-potato aphid.

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Section: Introductionmentioning

confidence: 99%

Biotransformation of Bicyclic Halolactones with a Methyl Group in the Cyclohexane Ring into Hydroxylactones and Their Biological Activity

et al. 2016

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“…Also, El-Shareif and Moussa have reported that 3,3í-(4,4í-Methylenebis(2,6-diethyl-4,1-phenylene))bis(1-(4ethoxyphenyl)-4-imino-5-thioxoimidazolidin-2-one) 118, 1-(4-chlorophenyl)-3-(3,4dichlorophenyl)-4thioxoimidazolidin-2-one 119, 1,3-bis(4-bromophenyl)-5-iminoimidazolidine-2,4-dithione 120 produced over 90% inhibition against Ehrlich Ascites carcinoma cells viability. These compounds have also cytotoxic activity against brain tumor cell line U251, human hepatocellular carcinoma cell HEPG2, human breast adenocarcinoma cell line MCF-7, and colon carcinoma cell line HCT116 (36,37).…”

Section: Antitumor Activitymentioning

confidence: 99%

Synthesis, Reactions, and Applications of Hydantoin and 2-Thiohydantoin Derivatives

Elhady¹,

Desoky²,

Al-Shareef³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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“…The all synthesized compounds showed grater inhibitory effects. 11 The development of cancer in various organs is often associated with chronic inflammation, suggesting a strong relationship between inflammation and carcinogenesis via. transcription factors and inflammatory mediators such as TNF, IL-1, IL-6, IL-10, NF-κB, STAT3, chemokines and COX-2.The nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are potent inhibitors of cyclooxygenase (COX).…”

Section: Substituted 3 4-dihydro-3 3-dimethyl-9-(substituted Phenylmentioning

confidence: 99%

Synthesis, Evaluation and Pharmacological Screening of 2, 3-Benzoquinoline Derivatives for Their Possible Anti-Inflammatory and Anti-Cancer Activity

Rathod¹,

Kshirsagar²,

Butle³

et al. 2019

Int Res J Pharm

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The 2, 3-Benzoquinoline derivatives have been synthesized by condensation of dimedone, aldehydes and aniline through conventional methods. Their chemical structures were identified by spectral analysis like FT-IR, 1H-NMR, and Mass spectrum. All the synthesized compounds of 2, 3-Benzoquinoline derivatives were screened for their possible anti-inflammatory and anticancer activity. In the present investigation test compounds R1, R2, and R3 were evaluated for in-vitro anti-inflammatory activity and in-vivo anticancer activity to provide the possible link between Inflammation and Inflammation Induced cancer. The results have clearly demonstrated that the compounds R1, R2, and R3 at different concentrations have good antiprotein denaturation activity; however it exhibited prominent anti-protein denaturation activity at its lowest concentration. The IC50 values of R1, R2, and R3 of the synthetic test compounds were found to be 115μg/ml, 99μg/ml, and 96μg/ml against MCF-7 cell. The study also demonstrated that the test compound R3 had greater inhibitory effects on the proliferation of the breast cancer cell line by inducing apoptosis as revealed by the expression of the apoptotic genes.

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Synthesis and characterization of new types of halogenated and alkylated imidazolidineiminothiones and a comparative study of their antitumor, antibacterial, and antifungal activities

Cited by 38 publications

References 57 publications

Biotransformation of Bicyclic Halolactones with a Methyl Group in the Cyclohexane Ring into Hydroxylactones and Their Biological Activity

Biotransformation of Bicyclic Halolactones with a Methyl Group in the Cyclohexane Ring into Hydroxylactones and Their Biological Activity

Synthesis, Reactions, and Applications of Hydantoin and 2-Thiohydantoin Derivatives

Synthesis, Evaluation and Pharmacological Screening of 2, 3-Benzoquinoline Derivatives for Their Possible Anti-Inflammatory and Anti-Cancer Activity

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