Synthesis and Characterization of New Fluoro/Trifluoromethyl-Substituted Acylthiourea Derivatives with Promising Activity against Planktonic and Biofilm-Embedded Microbial Cells

Limban, Carmen; Nuță, Diana Camelia; Missir, Alexandru Vasile; Roman, Roxana; Cãproiu, Miron Teodor; Dumitraşcu, Florea; Pintilie, Lucia; Stefaniu, Amalia; Chifiriuc, Mariana Carmen; Popa, Marcela; Zarafu, Irina; Arsene, Andreea Letiția; Pirvu, Cristina Elena Dinu; Udeanu, Denisa Ioana; Papacocea, Ioana Raluca

doi:10.3390/pr8050503

Cited by 13 publications

(12 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the ligandprotein complexes have been also realized based on Staphylococcus aureus DNA gyrase, taken from Protein Data Bank. The docking studies were performed according to the docking protocol described in a previous research work [26]. The molecular docking study expressed as docking score and the emphasized hydrogen bonds among tested ligands and proteins are listed in the Table IV.…”

Section: Molecular Docking Studiesmentioning

confidence: 99%

A Qsar Study on Thiourea Derivatives - New Approaches in Drug Development

Roman¹

2022

FARMACIA

Self Cite

View full text Add to dashboard Cite

The ongoing resistance to antibiotics constraints the research activity to design and develop new molecules, intended to overcome these necessities. In the current study, a series of organic compounds have been investigated for their properties, correlated to the potential of crossing biological membranes, consequently targeting a specific protein that would trigger an infectious disease in the body. On the matter, quantitative structureactivity relationship (QSAR) properties and molecular docking studies have been carried out for seven thiourea derivatives. The highly promising compounds have been nominated by software that ascertain if a specific molecule has an intended behaviour in the internal medium of the organism. RezumatRezistența continuă la antibiotice constrânge activitatea de cercetare spre dezvoltarea și proiectarea de noi molecule, menite să depășească aceste necesități. În studiul actual au fost investigate proprietățile unei serii de compuși organici, aceste proprietăți fiind corelate cu potențialul de traversare prin membranele biologice și, în final, cu țintirea unei proteine responsabile de instalarea infecției. În acest sens, proprietățile QSAR și studiile de andocare moleculară au fost efectuate pentru șapte derivați ai tioureei. Cei mai promițători compuși au fost selectați prin intermediul unor programe software, capabile să determine dacă o anumită moleculă are un comportament specific în mediul intern al organismului.

show abstract

Section: Molecular Docking Studiesmentioning

confidence: 99%

A Qsar Study on Thiourea Derivatives - New Approaches in Drug Development

Roman¹

2022

FARMACIA

Self Cite

View full text Add to dashboard Cite

show abstract

“…There is a tendency to switch from invasive sensors to non-invasive methods, to increase the life of the sensors from a maximum of 7 days to over a month or even years, and to provide safety against infections using specific coated materials (16)(17)(18).…”

Section: Continuous Glucose Monitoring Systems (Cgms): Characteristicsmentioning

confidence: 99%

Continuous glucose monitoring devices: A brief presentation (Review)

et al. 2021

View full text Add to dashboard Cite

As diabetes prevalence is continuously increasing, better management is needed to achieve blood glucose control, in order to prevent complications and lessen the burden of this disease. Since the first measurement of glycosuria at the beginning of the 1900s', huge advances were made in monitoring glycemia. Continuous glucose monitoring systems revolutionized diabetes management, especially for patients with type 1 diabetes. Avoiding glycemic variability and maintaining optimal glycemic control is crucial for the evolution of patients with type 1 diabetes. The usefulness of glycemic monitoring devices can be extended to patients with type 2 diabetes. It is also important to note that in those patients at risk of developing high glycemic variability (e.g. patients with advanced chronic kidney disease), continuous glycemic monitoring may improve their prognosis. These monitoring systems can be classified according to the analytical method, the degree of invasiveness, the data availability and the mode of usage. The technology is constantly improving in bioanalytical performance, biocompatibility, length of wearing time, safety and clinical features. The aim of this review was to briefly present the main characteristics of glucose biosensors, glucose monitoring systems and their clinically utility.

show abstract

“…Patents prefer due to user friendly and comfort with the sensors without pricking. Whereas the invasive glucose sensors need to be frequently changes for every 7 days for more accurate results need safety measure to prick and dispose the invasive sensor [15]- [17].…”

Section: Introductionmentioning

confidence: 99%

HI-Shaped antenna for non-invasive diabetic measurement and monitors fluctuating diabetes

Kirubakaran.S.J

Ananadan

N.R³

2022

Preprint

View full text Add to dashboard Cite

In this paper, HI- antenna is applied for monitoring the fluctuating diabetes. HI antenna senses the human pancreas dielectric radiation. HI antenna senses the radiation effectively because of shape and size of slot, which covers the pancreas region of human body, without change in crumbling effect during dielectric radiation signal acquisition. The dielectric radiations signal acquisition from pancreas lead to effective monitoring of fluctuating diabetes. However, traditional non-invasive method never monitors fluctuating diabetes, whereas they only measure diabetic value through non-invasive method. Non-invasive method of diabetic measurement never measures fluctuating diabetes due to improper mounting of sensor over the body is the major problem. The proposed HI-shaped antenna is mounted in different part of the human body such as hand, finger, stomach and pancreas for measuring fluctuating diabetes. Among the different part of body, optimized location is the pancreas of measuring diabetes is detected with proposed HI-shaped antenna. Moreover, different type of such as Microstrip antenna, log periodic antenna and are compared with the proposed HI-shaped antenna for diabetes measurement and proposed antenna dielectric signal statical values correlated with diabetic laboratory values. The proposed antenna measures the fluctuation diabetes with 85% accuracy.

show abstract

Synthesis and Characterization of New Fluoro/Trifluoromethyl-Substituted Acylthiourea Derivatives with Promising Activity against Planktonic and Biofilm-Embedded Microbial Cells

Cited by 13 publications

References 48 publications

A Qsar Study on Thiourea Derivatives - New Approaches in Drug Development

A Qsar Study on Thiourea Derivatives - New Approaches in Drug Development

Continuous glucose monitoring devices: A brief presentation (Review)

HI-Shaped antenna for non-invasive diabetic measurement and monitors fluctuating diabetes

Contact Info

Product

Resources

About