Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates

Abstract

Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) RSV conjugates with varying PCL chain lengths have been synthesised and formulated into micelles and/or nanoparticles for preliminaryin vitrostability studies. RSV conjugated with mPEG2000-PCL9500 was found to have improved solubility and stability of RSV as compared to RSV alone. The length of the PCL chain was found to affect the micelle formation, hence the stability in physiological buffers and rat plasma.

The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters

“…Hsu et al found that the combination of resveratrol with kefir could reduce fatigue and improve exercise performance in mice when administered as a food supplement [9]. Resveratrol has been successfully combined with other protective chemical groups [10,11]. Mattarei et al prepared amino acid carbamates as resveratrol prodrugs.…”