Synthesis and characterization of novel copper-doped modified bioactive glasses as advanced blood-contacting biomaterials

Tissue-engineered small-diameter vascular grafts containing novel copper-doped bioactive glass biomaterials to promote angiogenic activity and endothelial regeneration

“…The characterization of modified BGs was discussed in our previous study in detail [ 27 ]. XRD patterns of as-prepared modified BGs showed large halos, indicating their amorphous structure.…”

“…The modified BGs contained Cu in line with the nominal weight ratios and had no alumina or silicon contaminants, according to XRF analysis. In addition, the removal of calcium and phosphate components caused that none of the groups ruptured RBCs or activated the coagulation cascade, and the introduction of Cu ions to modified BGs significantly improved angiogenesis properties [ 27 ]. Accordingly, the synthesized modified BGs may be applied to vascular grafts without concern for coagulation.…”

“…Melt-quench was used to make the modified BGs from the 13–93B3 borate BG framework. According to our previous work, modified borate BGs were made using B 2 O 3 , MgO, K 2 O, Na 2 O, and CuO, while hemolytic components like calcium, phosphate, and silica were removed [ 27 ]. Sigma-Aldrich UK supplied reagent-grade precursors.…”

Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area

“…Moreover, the increased pH, therefore, can cause an inflammatory response also [ 122 ]. In a remarkably interesting and recent paper, Alasvand et al [ 123 ] developed a new type of bioglass that can be used as a blood-contact biomaterial. To date, this kind of application was confined by the fact that the BGs have a negative effect on the activation of the coagulation pathway.…”