Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies

Abstract

Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO4 acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were structurally characterized by microanalysis, magnetic susceptibility, FTIR, electronic spectra, TG/DTA, ESR, and molar conductance studies. Based on the spectral studies, the complexes have the general composition [VO(L)2] (C1) and [VO(L)phen] (C2) in a square pyramid geometrical fashion. The synthesized compounds were primarily screened for their in vitro growth inhibiting activity against different strains of bacteria, namely, E. coli, B. subtilis, S. aureus, and P. aeruginosa by the disc diffusion method. Also, the antifungal activity was determined against C. albicans and A. niger by the Bateman poisoned technique. The in vitro antioxidant activity of all the compounds was determined by DPPH free radical-scavenging assay. Intercalative mode of DNA-binding properties of the oxidovanadium(IV) complexes with calf-thymus DNA (CT-DNA) was investigated using UV, fluorescence spectra, and viscosity measurements.

Synthesis and structural characterization of oxovanadium(IV) complexes of dimedone derivatives

“…[10] Rising from the significant bioactive nature of a β-diketone and the biological function of vanadium, it was worth to merge the chemistry of β-diketones with that of vanadium to form a novel class of vanadiummetal-based β-diketones that could serve as potential anti-tumor agents against unaffected cancer cells. [11][12][13][14] In this study, we have synthesized three oxovanadium (IV) complexes with systematic variation of substituents and examined their structure using spectroscopic and physicochemical methods. The Intercalative mode of DNA-binding properties of the complexes with CT-DNA was investigated by using ultraviolet absorption spectra and viscosity measurements.…”

Synthesis, characterization and α‐amylase and α‐glucosidase inhibition studies of novel vanadyl chalcone complexes

“…[ 35 ] The oxido‐vanadium complexes show their characteristic VO band at 950–980 cm −1 in the spectrum. [ 36 ] The appearance and shifting of IR spectral peaks in the complexes are given in Table 1.…”

“…Moreover, g iso value indicated that a complex molecule was displaying a square pyramidal geometry. [ 36 ]…”

“…This enhancement in the activity of complexes comparative with the ligands can be attributed to the formation of large conjugated system and oxidation of V (IV) O 2+ to V (V) O + in the system. [ 36 ] The presence of the hydroxy group in L II may be the active factor for its antioxidant potential. The % inhibition data for ligand and complexes in given Table 4 and shown by the bar graph in Figure 6.…”

Synthesis, characterization, thermal, computational and biological activity studies of new potential bioactive diorganotin (IV) nitrosubstitutedhydroxamates‐A comparative study

“…The free radical‐scavenging activity of ligand and complexes is measured in terms of hydrogen donating or radical scavenging ability using the stable DPPH radical by the Blois method . The stock solutions of the ligand and complexes (100 μg/ml) were prepared in DMSO and their different concentrations (20–140 μL) were then prepared.…”