Synthesis and Characterization of Pectin/PVP Hydrogel Membranes for Drug Delivery System

Mishra, Rakesh K.; Datt, M.; Banthia, A. K.

doi:10.1208/s12249-008-9048-6

Cited by 181 publications

(88 citation statements)

References 35 publications

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“…Selection of a 3 mm/sec deformation rate was based on previous work with mucoadhesive films in which deformation rates ranged from 1 to 5 mm/sec. 8–10 Modulus (1.8–6.8 MPa) and tensile strength (2.1–4.2 MPa) of the PVP:CMC films decreased with increasing PVP content, which was contrary to results expected from PVP being considered the film-forming polymer. 17 While the observed tensile strength and modulus were comparable to mucoadhesive films prepared from chitosan/copolymer of polyvinyl alcohol (PVA)/polyethylene glycol (PEG) (UTS = 3.5–5.4 MPa and modulus = 2.7–7.5 MPa) 18 and copolymer of methylvinylether and maleic anhydride (UTS = 2.77 MPa) 8 , the UTS of PVP:CMC was 10 times lower than that for films made of hydroxypropylcellulose (20–110 MPa) and hydroxypropylmethylcellulose (HPMC; 40–150 MPa).…”

Section: Discussioncontrasting

confidence: 73%

Competing properties of mucoadhesive films designed for localized delivery of imiquimod

et al. 2013

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Oral mucosal delivery has gained prominence in the last two decades because the rich vasculature of the tissue enables rapid delivery and avoidance of first pass metabolism. Although commercial mucoadhesives are used for systemic delivery, systems are not currently available for treatment of local conditions. In the present work, mucoadhesive films are being developed for locally controlled release of an immune response modifier for preventing precancerous lesions from progressing to oral squamous cell carcinoma. Previous research showed that films composed of polyvinylpyrrolidone (PVP) and carboxymethylcellulose (CMC) released imiquimod in a sustained manner for 3 hr. In continuing development of the system, additional key properties were investigated with changes in composition. While adhesive properties in pull-off (0.42±0.03 to 1.1±0.1 N/cm2) and shear adhesion (1.7±0.25 to 5.6±1.4 N/cm2) increased with increasing PVP content of films, tensile properties, such as modulus (6.9±1.5 to 1.8±0.2 MPa) and ultimate strength (4.2±0.7 to 2.1±0.02 MPa), decreased as PVP content increased. Release profiles of the films showed that an increased PVP content resulted in burst release and faster erosion compared to sustained release and slower erosion with more CMC. Studies of transport kinetics showed that the films doubled the amount of imiquimod localized within epithelium compared to drug in solution, increasing their potential for local treatment of oral dysplasia. The mucoadhesive drug delivery system based on CMC and PVP offers a wide range of these properties without addition of new constituents.

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Section: Discussioncontrasting

confidence: 73%

Competing properties of mucoadhesive films designed for localized delivery of imiquimod

et al. 2013

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“…This is attributed to the increase in hydrogen bonding or strong intermolecular interaction between pectin and gelatin (Fig. 3) [38,39]. The peak at 1,018 cm −1 −1,052 cm −1 and 1,250 cm −1 −1,280 cm −1 indicated the C-O stretch of secondary alcoholic groups.…”

Section: Resultsmentioning

confidence: 96%

Development and characterization of pectin/gelatin hydrogel membranes for wound dressing

Mishra

Majeed

Banthia

2011

Int J Plast Technol

128

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The present work deals with the development of pectin-gelatin (PEGE) hydrogel membranes for wound dressing applications. The prepared hydrogels were characterized by FTIR spectroscopy, XRD spectroscopy, water vapor transmission rate (WVTR) test and tensile strength test. Morphology and thermal stability of the membranes were analyzed by Field emission scanning electron microscopy (FESEM) and thermogravimetric analysis (TGA). The swelling studies of the hydrogels were conducted in different pH buffer solutions (pH 1.4, 5.4, 7.4 and 9.4). FTIR spectra of the hydrogels indicated considerable lowering in usual -OH stretching vibration peak of pectin and gelatin, which suggests the development of probable intermolecular interactions between the two natural polymers. XRD study revealed the decrease in crystallinity of hydrogels as compared to parent pectin. The morphological analysis of the hydrogel revealed highly interconnected honeycomb type architecture with pore size ranging from 10 to 40 μm. It was found that increase in gelatin ratio significantly improves the porous nature of the membranes. TGA study showed the enhanced thermal stability of PEGE hydrogel as compared to reference pectin. Tensile strength (TS) and elongation at break (EB) was found to increase with gelatin content in the hydrogel membranes but further increase leads to decrease in TS and EB. The WVTR analysis of the membranes showed the moisture Int J Plast Technol (June 2011) 15(1):82-95 retentive properties indicating its possible use in moist wound care. The PEGE hydrogels were found to be cytocompatible with B16 melanoma cells.

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“…Hydrogels of PVP have limited applications because of its inferior mechanical properties. To increase its mechanical properties, PVP and its monomer, N-vinyl pyrrolidone, have been copolymerised with acrylic acid, methacrylates and other vinyl monomers (Zhao et al, 2006;Mishra et al, 2008). Furthermore, desired mechanical properties could be achieved by selecting a suitable cross-linking agent, degree of cross-linking and monomeric composition (Anseth et al, 1996;Devine, Higginbotham, 2005;Jin et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

Sohail

Khan

Shahzad

et al. 2014

Braz. J. Pharm. Sci.

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In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels under investigation. Swelling coefficient was high at higher pH values except for the one containing high PVP content. Drug release increased by increasing the pH of the medium and AA contents in hydrogels while increasing the concentration of cross-linking agent had the opposite effect. Analysis of the drug release mechanism revealed non-Fickian transport of tramadol from the hydrogels.Uniterms: Drugs/release. Hydrogels/pH sensitive. Polyvinylpyrrolidone-acrilic acid/hidrogels. Tramadol hydrochloride. Methylene bisacrylamide.Nesse estudo, preparamos hidrogéis de polivinilpirrolidona/ácido acrílico(PVP/AA), sensíveis ao pH, por meio de método de polimerização de radical livre, com variações no conteúdo de monômero, de polímero e de agente de ligação cruzada. O inchamento foi realizado em soluções tampão fosfato USP pH 1,2, 5,5, 6,5 e 7,5, com força iônica constante. A estrutura reticular foi avaliada por diferentes parâmetros e o FTIR confirmou a formação de hidrogéis de ligação cruzada. A cristalografia de raios X mostrou dispersão molecular do cloridrato de tramadol. Realizou-se estudo de liberação do fármaco em soluções tampão fosfato pH 1,2, 5,5 e 7,5 para amostras selecionadas. Observou-se que o inchamento e a liberação do fármaco dos hidrogéis podem ser modificados mudando-se a composição e o grau de ligação cruzada dos hidrogéis em estudo. O coeficiente de inchamento foi alto em pH mais altos, exceto para um deles com alto conteúdo de PVP. A liberação do fármaco aumentou com o aumento do pH do meio e do conteúdo em AA nos hidrogéis, enquanto que o aumento na concentração do agente de ligação cruzada apresentou efeito oposto. A análise do mecanismo de liberação do fármaco revelou transporte não Fickiano do tramadol dos hidrogéis.

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Synthesis and Characterization of Pectin/PVP Hydrogel Membranes for Drug Delivery System

Cited by 181 publications

References 35 publications

Competing properties of mucoadhesive films designed for localized delivery of imiquimod

Competing properties of mucoadhesive films designed for localized delivery of imiquimod

Development and characterization of pectin/gelatin hydrogel membranes for wound dressing

pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

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