Synthesis and characterization of PEG coated hollow Fe3O4 magnetic nanoparticles as a drug carrier

Da, Xianhong; Li, Ruonan; Li, Xiang; Lu, Yin; Gu, Fenfen; Liu, Yan

doi:10.1016/j.matlet.2021.131357

Cited by 16 publications

(5 citation statements)

References 16 publications

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“…Meanwhile, the morphology of IONPs generated through coprecipitation is challenging to regulate due to the complex intermediate phase conversion and a series of physical and chemical processes. − The correlation between the structure and performance of IONPs has emerged as a focal point in current research. ,, As an essential parameter of the structure, morphology has a profound impact on the performance of nanoparticles. Anisotropic-shaped IONPs exhibit higher performance in MRI. − The changes in the morphology of IONPs can lead to an increase in the nonuniformity and disturbance area of the excitation magnetic field. This will increase the range of action of IONPs on surrounding water protons, thereby enhancing the T 2 relaxation ability of IONPs. , Researchers utilized the thermal decomposition of iron precursors in high-boiling organic solvents to synthesize IONPs with enhanced magnetic characteristics and anisotropic shape. − Nevertheless, the organic solvent is hard to entirely isolate during this procedure, leading to the possible biological toxicity of clinical application .…”

Section: Introductionmentioning

confidence: 99%

Polyhedral Magnetic Nanoparticles of High Magnetization Synthesized by Hydrocooling and Magnetically Internal Heating Coprecipitation: Implications for Magnetic Resonance Imaging

Zhang,

Deng,

Yao

et al. 2024

ACS Appl. Nano Mater.

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The coprecipitation method is widely recognized as a green, biocompatible, and low-cost synthetic pathway. However, the conventional coprecipitation approach used for generating iron oxide nanoparticles (IONPs) yields particles with inadequate crystallinity and magnetism and challenges in controlling their morphology. These limitations restrict the potential uses of IONPs in magnetic resonance imaging (MRI). This study introduces a technique called hydrocooling and magnetically internal heating coprecipitation (HMIHC) to address these limitations and enhance the MRI performance of IONPs. The introduction of an alternating magnetic field (AMF) accelerates the self-ripening process of IONPs and facilitates an ordered arrangement of magnetic moments within the IONPs. Simultaneously, precise control over the phase change is achieved by gradually introducing a NaOH solution, leading to the synthesis of polyhedral IONPs. The polyhedral IONPs produced via HMIHC exhibit extraordinary magnetism and a high r 2 value, and these IONPs exhibit excellent MRI capabilities. This research reveals the significant potential of HMIHC in the production of magnetic nanomaterials for MRI.

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Section: Introductionmentioning

confidence: 99%

Polyhedral Magnetic Nanoparticles of High Magnetization Synthesized by Hydrocooling and Magnetically Internal Heating Coprecipitation: Implications for Magnetic Resonance Imaging

Zhang,

Deng,

Yao

et al. 2024

ACS Appl. Nano Mater.

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“…Additionally, magnetic materials can be coated with various coatings simultaneously, further expanding their versatility and applicability [73]. In the biomedical field, magnetic particles and magnetic composites are utilized as drug carriers [74][75][76][77][78][79][80][81], as contrast agents for magnetic resonance imaging (MRI) [82][83][84][85][86][87], and in magnetic hyperthermia (MH) [26,55,77,80,[88][89][90][91][92][93][94][95][96][97][98], which is also a focus of this short review.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Beković,

Ban,

Drofenik

et al. 2023

Applied Sciences

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This concise review delves into the realm of superparamagnetic nanoparticles, specifically focusing on Fe2O3, Mg1+xFe2−2xTixO4, Ni1−xCux, and CrxNi1−x, along with their synthesis methods and applications in magnetic hyperthermia. Remarkable advancements have been made in controlling the size and shape of these nanoparticles, achieved through various synthesis techniques such as coprecipitation, mechanical milling, microemulsion, and sol–gel synthesis. Through this review, our objective is to present the outcomes of diverse synthesis methods, the surface treatment of superparamagnetic nanoparticles, their magnetic properties, and Curie temperature, and elucidate their impact on heating efficiency when subjected to high-frequency magnetic fields.

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“…Da et al have reported the fabrication of polyethylene glycolcoated Fe3O4-based nanoparticles loaded with doxorubicin as a drug carrier for tumor therapy. The nanorings and nanotubes demonstrated superior drug carrier and release performances compared to the nanospheres [23]. Nanoparticles have gained widespread use in cancer therapy due to their ability to deliver drugs specifically to tumor sites while minimizing side effects [24].…”

Section: Introductionmentioning

confidence: 99%

“…According to Gomez-Estaca et al, the electrospray technique or electrohydrodynamic atomization (EHDA) offers advantages for nanoparticle synthesis, including high encapsulation efficiency and no need for particle separation from the solvent [29]. Additionally, electrospray enables the formation of particles with varying diameters, uniform size distribution, and distinct morphologies [23], [30], [31]. This study also investigated the use of chitosan nanoparticles as drug carriers for cancer treatment using the electrospray technique.…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Chitosan Nanoparticles for Drug Carriers in Cancer Treatment - A Mini Review

Udaneni,

Azizah,

Harjunowibowo

et al. 2023

JBBBE

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Nanoparticles have emerged as promising tools for cancer treatment due to their ability to selectively deliver drugs to the tumor site while avoiding significant systemic side effects. Chitosan nanoparticles, among various types of nanoparticles, have gained significant attention due to their biocompatibility, biodegradability, and local drug delivery capacity. The electrospray technique is an efficient method for preparing chitosan nanoparticles, offering reproducibility, scalability, and high drug encapsulation efficiency. This technique has gained popularity due to its ease of use and flexibility in meeting various demands of nanoparticle production. Recent studies have investigated the potential of chitosan nanoparticles prepared by electrospray technique to encapsulate a range of drugs. The method leverages active surface absorption, binding, or complexation with drugs. For example, chitosan-based nanoparticles loaded with DOX and QUE achieved high encapsulation efficiency of 83% and effectively inhibited the growth of HCT-116 cancer cells. Similarly, SNP-CH-DOX-CM nanoparticles showed significant anti-cancer activity against HepG2 tumors. However, it should be noted that the toxicity of nanoparticles is directly related to the concentration of the active substance. Therefore, careful optimization of drug dosing is necessary to minimize any potential toxicity.

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Synthesis and characterization of PEG coated hollow Fe3O4 magnetic nanoparticles as a drug carrier

Cited by 16 publications

References 16 publications

Polyhedral Magnetic Nanoparticles of High Magnetization Synthesized by Hydrocooling and Magnetically Internal Heating Coprecipitation: Implications for Magnetic Resonance Imaging

Polyhedral Magnetic Nanoparticles of High Magnetization Synthesized by Hydrocooling and Magnetically Internal Heating Coprecipitation: Implications for Magnetic Resonance Imaging

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Electrosprayed Chitosan Nanoparticles for Drug Carriers in Cancer Treatment - A Mini Review

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